Evidence map›Paper›PMID 41086711›Full record

ArticleJournal of biomechanics2025

An experimental-computational approach for measuring charged solute diffusivity through human synovium.

Alexandra L Davis, Ashish Vaidyanathan, Sarah Owusu Sachie, Milad Rohanifar, Liufang Jing, Shamimur R Akanda, Lori A Setton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra L DavisDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: alexandradavis@wustl.edu.
Ashish VaidyanathanDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: a.vaidyanathan@wustl.edu.
Sarah Owusu SachieDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: sachie@wustl.edu.
Milad RohanifarDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: milad.roohanifar@gmail.com.
Liufang JingDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: liufangjing@wustl.edu.
Shamimur R AkandaDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: akanda@wustl.edu.
Lori A SettonDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: setton@wustl.edu.

Funding

Intra-Articular Delivery of Sustained Release NF-kB Antagonists In ArthritisR01AR070975 · NIAMS · WASHINGTON UNIVERSITY · PI SETTON, LORI A. · 2017 to 2021
$1.7M
NIAMS NIH HHS R01 AR070975
6 · The paper itself

Abstract

Intra-articular drug delivery has shown promise in targeting arthritic joints, but its therapeutic efficacy is hindered by the synovium, a multilayered connective tissue that rapidly clears locally delivered drugs from the joint space. To better understand the mechanisms behind synovial drug clearance, we previously developed a finite element model of synovium as a multiphasic tissue and used an inverse method to determine the effective diffusivity (D

Indexed as

DextransModels, BiologicalSynovial MembraneComputer SimulationDiffusionFinite Element AnalysisHumansMolecular WeightDextransArthritisDrug deliveryFinite element modelingIntra-articularMultiphasicSolute transportSynovium

Identifiers

PMID41086711
PMCPMC12548822

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.