Evidence map›Paper›PMID 41086653›Full record

ReviewBioorganic & medicinal chemistry2026

RNA modifications in cancer: from biological insights to therapeutic targets.

Yutao Zhao, Chuan He

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioorganic & medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yutao ZhaoDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Mechanosensitive M7G epitranscriptome in endothelial health and diseaseR01HL155909 · NHLBI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2022 to 2025
$2.8M
NHGRI NIH HHS RM1 HG008935NHLBI NIH HHS R01 HL155909
6 · The paper itself

Abstract

RNA modifications represent an essential regulatory layer of gene expression and have profound implications for cellular homeostasis and human diseases. Advances in high-throughput sequencing technologies have revealed that modifications such as N

Indexed as

Antineoplastic AgentsNeoplasmsRNAAdenosineAnimalsHumansRNA Processing, Post-TranscriptionalSmall Molecule LibrariesAdenosineAntineoplastic AgentsRNASmall Molecule LibrariesCancer biologyEpitranscriptomicsN6-methyladenosine (m6A)Pseudouridine (Ψ)RNA modificationsSmall-molecule inhibitors

Identifiers

PMID41086653
PMCPMC12529797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.