Evidence map›Paper›PMID 41086611›Full record

ArticleStem cell research2025

Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome.

Holly N Cukier, Brooke A DeRosa, Lauren E Coombs, Eugene Tang, Denise R Leyva, Ainnara R Lazzaro, Esther Gu, Derek M Dykxhoorn, Jonathan L Haines, Margaret A Pericak-Vance and 3 more

Abstract read
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In one paragraph

Article in Stem cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Holly N CukierJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA; John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, USA. Electronic address: hcukier@med.miami.edu.
Brooke A DeRosaJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA.
Lauren E CoombsJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA.
Eugene TangJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA.
Denise R LeyvaJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA.
Ainnara R LazzaroJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA; JJ Vance Memorial Summer Internship in Biological and Computational Sciences, University of Miami Miller School of Medicine, USA.
Esther GuJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA.
Derek M DykxhoornJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA; John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, USA.
Jonathan L HainesDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, USA; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, USA; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, USA.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA; John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, USA.
Yeunjoo E SongDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, USA.
William S BushDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, USA; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, USA; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, USA.
Anthony J GriswoldJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, USA; John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, USA.

Funding

Additional Sequencing for the Alzheimer Disease Sequencing Project (ADSP) the Follow-Up Study (FUS), The Global Population InitiativeU01AG076482 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Clifton L Dalgard, ANTHONY JOHN GRISWOLD · 2022 to 2026
$26.9M
Summer Research Experience in Biological and Computational SciencesR25NS090624 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI JEFFERY Marvin VANCE · 2014 to 2026
$1.2M
Investigating Genomic Instability and Loss of the Y Chromosome in Alzheimer’s DiseaseR21AG079196 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CUKIER, HOLLY N, GRISWOLD, ANTHONY JOHN · 2023 to 2023
$422k
NIA NIH HHS R21 AG079196NIA NIH HHS U01 AG076482NINDS NIH HHS R25 NS090624
6 · The paper itself

Abstract

Mosaic loss of the Y chromosome (LOY) is a somatic phenomenon that occurs in males as they age (Jacobs, 1963; Forsberg, 2017; Danielsson, 2020) and is associated with an elevated risk of developing numerous diseases, including Alzheimer's Disease (AD) (Dumanski, 2016; Palmer, et al., 2022; Garcia-Gonzalez, 2023), cancer (Holmes, 1985; Loftfield, 2018), diabetes (Loftfield, 2018), age related macular degeneration (Grassmann, 2019), and autoimmune disease (Persani, 2012; Lleo, 2013). The induced pluripotent cell lines (iPSCs) UMi050-A and UMi050-B were derived from a Hispanic male with loss of the Y chromosome in his blood and diagnosed with AD. This isogenic pair of lines with and without a Y chromosome is a unique resource to delve into the mechanism of LOY and its relationship to AD risk.

Indexed as

Alzheimer DiseaseChromosomes, Human, YInduced Pluripotent Stem CellsCell LineHispanic or LatinoHumansMaleMosaicism

Identifiers

PMID41086611
PMCPMC12818727

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.