ArticleHuman vaccines & immunotherapeutics2025
Humoral immune responses to the second dose of a COVID-19 mRNA vaccine in cancer patients undergoing treatment.
Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Neutralizing antibody responses to the primary series of a COVID-19 mRNA vaccine in the cancer cohort under active treatment.Human vaccines & immunotherapeutics · 2025Article
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15 authors.
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Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in 2020 led to the immediate development of vaccines to combat SARS-CoV-2 infections and coronavirus disease 2019 (COVID-19). First-generation (2020-2021) COVID-19 vaccines demonstrated high immunogenicity and efficacy, successfully reducing hospitalization, disease severity and COVID-19 related deaths. However, the initial clinical trials for these vaccines focused on overall healthy individuals, and generally excluded high risk populations, such as people with cancer. The SARS-CoV-2 VaccinE Response, Immunological eFfects and safetY in patients with Cancer (VERIFY-C) study formed a unique cohort in early 2021, to capture the initial immune response to BNT162b2 mRNA (Pfizer) vaccination in people with cancer, with or without ongoing/recent exposure to systemic cancer treatment. Fifty-three participants diagnosed with cancer were enrolled. Majority were non-Hispanic, Caucasian females. Patients under cancer treatment had significantly lower antibody responses than those without treatment at pre-second dose and 1-month post-second dose. The levels at 6-months post-second dose were similar between both groups. Patients under treatment had a significantly lower immune response 1-month post-second dose, with an increased immune response at 6-months post-second dose, suggesting a delayed immune response. Further investigations are needed to understand antibody functionality post-vaccination in these individuals.
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