Evidence map›Paper›PMID 41086320›Full record

ReviewPain2025

Neuropharmacology and physiology of human dorsal root ganglion neurons responsible for nociception: state-of-the-art and future directions.

Jayden A O'Brien, Joseph B Lesnak, Theodore J Price

Abstract readReview
In one paragraph

Review in Pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jayden A O'BrienCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas, Richardson, TX, United States.
Joseph B Lesnak

Funding

Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6M
NINDS NIH HHS NS130608NINDS NIH HHS U19 NS130608
6 · The paper itself

Abstract

abstractOver the past 50 years, we have gone from the discovery of nociceptors in the dorsal root ganglion (DRG) to an appreciation of the contribution of individual cell types to specific nociceptive behaviors in mice and to characterization of the molecular composition of DRG neurons in mice and humans. We appraise what we know about nociceptors in humans, with a focus on what features of their physiology and pharmacology are important for acute and chronic pain. We then discuss what advances are on the horizon and how targeting these cells with therapeutics can revolutionize the way that pain is treated.

Indexed as

Ganglia, SpinalNeuronsNeuropharmacologyNociceptionNociceptorsPainAnimalsHumansDRGHumanized modelNeuropeptidesNociceptors

Identifiers

PMID41086320
PMCPMC12614240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.