ArticleJMIR research protocols2025
Efficacy of Canaloplasty for the Management of Primary Open-Angle Glaucoma: Protocol for a Systematic Review.
Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlaucoma forms the leading cause of irreversible blindness worldwide, with a disproportionately rising prevalence in Asian and African countries. Primary open-angle glaucoma (POAG) accounts for the majority of cases. Medical therapies for POAG are not without side effects, and surgical treatments carry high complication rates. Ab interno canaloplasty promises a safer, minimally invasive, yet effective treatment option for mild-to-moderate POAG, as well as a cost-effective technique for low-resource countries. However, no systematic review currently exists to verify this procedure's efficacy.
objectiveThe aim of this study was to develop a protocol for a systematic review aimed at evaluating the efficacy of canaloplasty against all other forms of POAG treatment.
methodsThis systematic review and meta-analysis will include randomized controlled trials evaluating the short-term, medium-term, and long-term efficacy and safety of ab interno canaloplasty in treating POAG in comparison to all other treatments. Mean changes in intraocular pressure will form the primary outcome measure. Secondary outcome measures include proportion of participants who are medication-free after treatment and mean changes in the health-related quality of life. MEDLINE, Embase, Cochrane Library, and ClinicalTrials.gov databases will be searched for relevant randomized controlled trials. All studies will be subject to prespecified inclusion and exclusion criteria. The quality of the eligible randomized controlled trials will be assessed using the Cochrane risk of bias tool. Data will be extracted with a focus on raw data where possible, and analysis will be performed using RevMan 5.4 software to compare the mean changes in intraocular pressure (mm Hg) between ab interno canaloplasty and other comparator therapies. A funnel plot will be used to assess the risk of publication bias if 10 or more trials are included in the review. I
resultsThe results of this systematic review are not yet available as it is still at the protocol stage. This protocol was registered on the PROSPERO database for systematic reviews (CRD42024558671) on June 27, 2024. Data collection for this review began on July 14, 2024, with the anticipated completion date being early 2026.
conclusionsThe findings will be important to patients, clinicians, and policymakers worldwide in addressing the growing burden and health inequality of glaucoma.
trial registrationPROSPERO CRD42024558671; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024558671. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/69527.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.