Trial reportHuman brain mapping2025
Physical Activity and BrainAGE: Exploring the Impact on Brain Health and Plasticity in Older Adults.
Trial report in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Physical Activity and BrainAGE: Exploring the Impact on Brain Health and Plasticity in Older Adults.Human brain mapping · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
With an aging global population, cognitive decline in older adults presents significant healthcare challenges. Emerging evidence suggests that physical activity can support cognitive health by promoting plasticity, functional reorganization, and structural adaptation of the brain. In the FIT4BRAIN study, we examined the effects of multi-component physical activity on cognitive and brain health. Here, we report the results on one of the secondary outcomes, namely changes in brain age (BrainAGE), which estimates the difference between chronological and predicted brain age based on structural MRI data, and changes in brain structure, assessed through voxel-based morphometry (VBM). Ninety-two healthy older adults were randomized into a multi-component physical activity group, performing aerobic, coordination, and balance exercises, or an active control group engaging in non-aerobic relaxation exercises and educational content (physical activity group (PAG): 36 participants; active control group (CON): 33 participants). Of these, 69 participants underwent MRI assessment and were included in the present analyses. BrainAGE analyses revealed a greater decrease in the physical activity group compared to the control group, indicating a beneficial effect of physical activity on brain aging. Subgroup analyses based on baseline cardiorespiratory fitness (CRF) further revealed that participants with lower CRF showed greater benefits, consistent with VBM findings of structural changes in the same subgroup. These results underscore BrainAGE as a sensitive biomarker for intervention outcomes and suggest that stratification by baseline fitness level may help identify differences in the benefits of physical activity on brain health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.