Evidence map›Paper›PMID 41085948›Full record

ArticleGeneral thoracic and cardiovascular surgery2026

Prognostic significance of postoperative serum C-reactive protein levels after minimally invasive esophagectomy for esophageal cancer.

Hirotaka Ishida, Toshiaki Fukutomi, Yusuke Taniyama, Chiaki Sato, Hiroshi Okamoto, Yohei Ozawa, Jun Takahashi, Iku Sasaki-Higashimoto, Michiaki Unno, Takashi Kamei

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Article in General thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hirotaka IshidaDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan. h-ishida@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-6814-3564
Toshiaki FukutomiDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Yusuke TaniyamaDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Chiaki SatoDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Hiroshi OkamotoDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Yohei OzawaDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Jun TakahashiDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Iku Sasaki-HigashimotoDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Michiaki UnnoDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.
Takashi KameiDepartment of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePostoperative inflammation can promote immunosuppression and cancer recurrence. The present study investigated the correlation between serum C-reactive protein (CRP) levels after minimally invasive esophagectomy and long-term patient outcomes with large scale of cases.

methodsData from 329 patients who underwent minimally invasive esophagectomy were analyzed. Serum CRP levels were measured from postoperative day (POD) 1 to 7, 10, and 14. Low and high CRP groups were stratified by the median CRP values for each POD. Overall survival (OS) was defined as the time from esophagectomy to patient death. Relapse-free survival (RFS) was defined as the time to disease relapse or death from other cause.

resultsThe high CRP group on PODs 5-7 and 10 had a significantly lower OS rate than the low CRP group. The high CRP group on POD 6, 7, and 10 also had a significantly lower RFS rate than the low CRP group. A high CRP level on POD 7 was identified as an independent risk factor for poor OS/RFS. In contrast, preoperative CRP levels (before esophagectomy) were not identified as a risk factor for unfavorable OS/RFS. The high CRP group had a higher mortality rate from other diseases than the low CRP group (15.0% vs 8.9%). Secondary malignancies tended to be more frequent in the high CRP group than in the low CRP group (26.1% vs 6.3%).

conclusionElevated CRP levels in the immediate postoperative period after minimally invasive esophagectomy, particularly on POD 7, were significantly associated with poor OS and RFS.

Indexed as

C-Reactive ProteinEsophageal NeoplasmsEsophagectomyInflammation MediatorsAgedBiomarkersDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMinimally Invasive Surgical ProceduresPredictive Value of TestsRetrospective StudiesRisk FactorsBiomarkersC-Reactive ProteinInflammation MediatorsC-reactive proteinEsophageal cancerMinimally invasive esophagectomyPrognosis

Identifiers

PMID41085948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.