Evidence map›Paper›PMID 41085944›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026

Isochronal late activation mapping in ischemic scar VT: an independent validation using intraoperative mapping.

Takahiro Hayashi, Erica Muscat, Mahbod Rahimi, Stephane Masse, Arulalan Veluppillai, Krishnakumar Mohanan Nair, Andrew Ha, Kumaraswamy Nanthakumar, Eugene Downar, Abhishek Bhaskaran

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takahiro HayashiDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Erica MuscatDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Mahbod RahimiDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Stephane MasseDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Arulalan VeluppillaiDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Krishnakumar Mohanan NairSunnybrook hospital, Toronto, Ontario, Canada.
Andrew HaDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Kumaraswamy NanthakumarDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Eugene DownarDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada.
Abhishek BhaskaranDivision of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network Toronto, 150 Gerrard Street West, GW3-552, Toronto, Ontario, M5G 2C4, Canada. Abhishek.Bhaskaran@uhn.ca.ORCID http://orcid.org/0000-0003-2963-4907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVT ablation is often limited by hemodynamic instability. Substrate-based ablation strategy is often useful, and isochronal late activation mapping (ILAM) in sinus rhythm (SR) to identify deceleration zones (DZ) has been reported to be effective.

aimWe aimed at independently validating ILAM concept using data from comprehensive intraoperative VT mapping.

methodPanoramic simultaneous endocardial intraoperative mapping was performed using a 112 bipolar electrode balloon. The late potentials in SR were mapped in eight isochrones, each of 15-30ms duration and correlated to the diastolic path of induced VT. Deceleration zone was defined as the presence of three or more isochrones within a radius of one centimetre. This equates to 10-20 cm/s of apparent conduction velocity.

resultTwenty-five VTs with complete mapped diastolic path were studied in 12 patients. Diastolic path of 17/25(68%) VTs harboured at least one DZ. Overall, 27 DZ were identified with mean of 2.25 per patient. The average conduction velocity in the DZ was 11 ± 2 cm/s.

conclusionConduction slowing identified by isochronal late activation mapping during sinus rhythm colocalized with two-thirds of VT diastolic paths in ischemic heart disease patients.

Indexed as

Body Surface Potential MappingCatheter AblationCicatrixMyocardial IschemiaTachycardia, VentricularAgedElectrocardiographyFemaleHeart Conduction SystemHumansMaleMiddle AgedMonitoring, IntraoperativeReproducibility of ResultsTreatment OutcomeAblationILAMVentricular tachycardia

Identifiers

PMID41085944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.