Evidence map›Paper›PMID 41085934›Full record

ReviewJournal of cardiovascular translational research2025

Gene Therapies in Atrial Fibrillation.

Cian O'Donnell, Aleksei Mikhailov, Shin Yoo, Asish Ghosh, Rishi Arora

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cian O'DonnellSection of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0009-0008-5143-2934
Aleksei MikhailovSection of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Shin YooSection of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Asish GhoshSection of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Rishi AroraSection of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA. Rishi.Arora@bsd.uchicago.edu.ORCID 0000-0002-0725-4332

Funding

New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial FibrillationR35HL161249 · NHLBI · UNIVERSITY OF CHICAGO · PI Rishi Arora · 2022 to 2026
$5.1M
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heartR01HL152712 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI, ZHAO, MING · 2021 to 2024
$3.0M
Pathophysiological Significance of Atrial Fibrillation Electrogram PatternsR01HL168117 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI JEFFREY J GOLDBERGER · 2023 to 2026
$2.7M
NHLBI NIH HHS R01 HL152712NHLBI NIH HHS R01 HL168117NHLBI NIH HHS R35 HL161249
6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet current therapies-including drugs and catheter ablation-remain suboptimal. Gene therapy offers a promising way to modulate AF's molecular drivers. This review summarizes recent preclinical studies using viral and non-viral vectors, atrial-specific delivery strategies, and key targets such as ion channels, fibrosis, and oxidative stress. Despite promising results, no AF gene therapy has FDA approval, due to challenges in atrial targeting, immune control, and durable expression. Closing this translational gap is critical for future AF gene therapy.

Indexed as

Atrial FibrillationGenetic TherapyHeart RateAction PotentialsAnimalsGenetic VectorsGene Transfer TechniquesHumansIon ChannelsOxidative StressTreatment OutcomeIon ChannelsAtrial fibrillationElectrical remodelingGene therapyOxidative stressStructural remodeling

Identifiers

PMID41085934
PMCPMC12701035

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.