Evidence map›Paper›PMID 41085918›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Brain linear measurement index in the differential diagnosis between idiopathic normal pressure hydrocephalus and progressive supranuclear palsy.

Antonina Luca, Giulia Donzuso, Federico Contrafatto, Giovanni Mostile, Calogero Edoardo Cicero, Alessandra Nicoletti, Mario Zappia

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Antonina Luca *School of Medicine and Surgery, Kore University of Enna, Enna, Italy.ORCID http://orcid.org/0000-0002-8397-3478
Giulia Donzuso *Department of Medical, Surgical and Advanced Technologies, "GF Ingrassia", University of Catania, Via Santa Sofia 78, Catania, 95123, Italy.ORCID http://orcid.org/0000-0003-4925-694X
Federico ContrafattoDepartment of Medical, Surgical and Advanced Technologies, "GF Ingrassia", University of Catania, Via Santa Sofia 78, Catania, 95123, Italy.
Giovanni MostileDepartment of Medical, Surgical and Advanced Technologies, "GF Ingrassia", University of Catania, Via Santa Sofia 78, Catania, 95123, Italy.ORCID http://orcid.org/0000-0002-3556-7432
Calogero Edoardo CiceroDepartment of Medical, Surgical and Advanced Technologies, "GF Ingrassia", University of Catania, Via Santa Sofia 78, Catania, 95123, Italy.ORCID http://orcid.org/0000-0002-8647-8851
Alessandra NicolettiDepartment of Medical, Surgical and Advanced Technologies, "GF Ingrassia", University of Catania, Via Santa Sofia 78, Catania, 95123, Italy.ORCID http://orcid.org/0000-0001-6757-340X
Mario ZappiaDepartment of Medical, Surgical and Advanced Technologies, "GF Ingrassia", University of Catania, Via Santa Sofia 78, Catania, 95123, Italy. m.zappia@unict.it.ORCID http://orcid.org/0000-0002-8298-9486

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDifferential diagnosis between idiopathic normal pressure hydrocephalus (iNPH) and progressive supranuclear palsy (PSP) could be challenging, due to the presence of similar clinical and neuroradiological features. Aim of this retrospective study was to differentiate iNPH from PSP by means of brain linear measurement (BLM) index. MATERIALS AND

methodsAll the enrolled patients underwent a 1.5-T brain-MRI and BLM index was calculated on T1-weighted images. The magnetic resonance hydrocephalic index (MRHI) was also measured. For each index, receiver operating characteristic (ROC) analyses were performed to differentiate between iNPH and PSP obtaining the area under the curve (AUC), sensitivity, specificity, and accuracy values.

resultsSeventy-three patients (35 iNPH and 39 PSP) were consecutively enrolled. BLM and MRHI were significantly higher in iNPH patients than in PSP. In differentiating iNPH from PSP, the BLM index had the highest AUC (0.997) with a sensitivity of 97.1%, a specificity of 100% and an accuracy of 98.6% with an optimal cut-off value of 0.285.

conclusionBLM may be useful in the differential diagnosis between iNPH and PSP. At an individual level, the BLM index was the most accurate measure, representing a valid, easy and reliable tool, to achieve an accurate differentiation between these two conditions.

Indexed as

BrainHydrocephalus, Normal PressureSupranuclear Palsy, ProgressiveAgedAged, 80 and overDiagnosis, DifferentialFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesROC CurveSensitivity and SpecificityDiagnosisIdiopathic normal pressure hydrocephalusMagnetic resonance imagingProgressive supranuclear palsy,

Identifiers

PMID41085918
PMCPMC12678465

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