SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Physical exercise and inflammation in Parkinson's disease: a review.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise as a potent antidepressant intervention in Parkinson's disease: a systematic review and meta-analysis of randomised controlled trials.Frontiers in psychology · 2026Pooled it
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Activation of the Nrf2-ARE Signaling Pathway Mediates the Neuroprotective Effects of Exercise in a Mouse Model of Chronic Parkinson's Disease.International journal of molecular sciences · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionStudies have shown that neuroinflammation plays an important role in Parkinson's disease (PD). Current clinical studies provide evidence that physical exercise may enhance pharmacological treatment and alleviate motor impairments in PD patients. However, current understanding of the anti-inflammatory effects of physical exercise in PD is limited. This article reviewed the current state of knowledge concerning the anti-inflammatory properties of physical exercise as an effective therapy for PD.
methodsA systematic search was conducted for articles published in PubMed, EMBASE and Web of Science from Jan 1973 to Jun 2025.
resultsA total of 41 articles were included in the study. Physical exercise may prevent neurodegeneration in dopaminergic neurons via the inhibition of inflammatory processes. This includes alleviating the inflammatory activity of glia cells, modulating inflammasomes and inflammatory factors through inflammatory pathways and altering the composition of the gut microbiota.
conclusionThis review presents the current evidence supporting the anti-inflammatory effects of physical exercise as a potential therapy for PD. However, it is not clear how inflammation can further cause the continuous degeneration of dopaminergic neurons, and the specific neuroimmune-modifying mechanism of exercise needs further research.
Indexed as
Identifiers
41085917What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.