Evidence map›Paper›PMID 41085847›Full record

ArticleDiscover oncology2025

Mapping the global intellectual landscape of inflammatory tumor microenvironment in colorectal cancer pathogenesis and prognostic research since this century.

Hui Mu, Yushu Zhu, Feihu Yan, Can Lv, Xiaoyu Tu, Junyan He, Zhaoming Wang, Yi Zeng, Zhiwei Liu, Jiaojiao Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hui MuDepartment of Clinical Nutrition, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Yushu ZhuDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Feihu YanDepartment of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Can LvSchool of Traditional Chinese Medicine, Naval Medical University, Shanghai, 200433, China.
Xiaoyu TuSchool of Traditional Chinese Medicine, Naval Medical University, Shanghai, 200433, China.
Junyan HeSchool of Traditional Chinese Medicine, Naval Medical University, Shanghai, 200433, China.
Zhaoming WangDepartment of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Yi ZengDepartment of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Zhiwei LiuDepartment of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jiaojiao ChenDepartment of Chinese Medicine and Oncology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Bai LiSchool of Traditional Chinese Medicine, Naval Medical University, Shanghai, 200433, China. libai9@126.com.
Enda YuDepartment of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. yuenda@163.com.
Xuan ZhengDepartment of Clinical Nutrition, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. 13917144159@163.com.

Funding

"Deep Blue" talent project, "sailing program" funding of PLA Naval Military Medical University 202128"Medicine New Star" of Shanghai, China 202265Special clinical research project of health industry of Shanghai Municipal Health Commission 20224Y0075Youth program of National Natural Science Foundation of China 81802434
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is one of the most prevalent gastrointestinal tumors worldwide. Complex interactions between tumor microenvironment (TME) and host inflammatory response influence CRC progression and recurrence. The current study provides a comprehensive bibliometric visualization of the current state and frontier trends of inflammatory TME in CRC. MATERIALS AND

methodsScientific publications on the inflammatory TME in CRC from 2000 to 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. Biblioshiny software was mainly applied for visualization and analysis of literature. CiteSpace software and VOSviewer software were used to validate the results.

resultsA total of 1593 articles related to CRC inflammatory TME have been retrieved since the 21st century. Cancers and Frontiers in Immunology were the two most popular journals, and Cancer Research is the most cited journal. Mcmillan DC, Park JH and Mantovani A were the most academic influential authors in inflammatory TME in CRC.

conclusionsThis study preliminary visualize the association of inflammatory TME with CRC through bibliometric analysis. The immunomodulatory mechanisms in IBD-associated carcinogenesis, NF-κB-mediated TME remodeling in tumor progression, and CRC patient stratification and precision therapeutics were three hotspots for future research endeavors on the inflammatory TME in CRC research.

Indexed as

Colorectal cancerInflammationTumor microenvironment

Identifiers

PMID41085847
PMCPMC12521722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.