Evidence map›Paper›PMID 41085834›Full record

ReviewJournal of gastrointestinal cancer2025

C. difficile Infection in Colorectal Cancer: Risk Determinants, Outcomes, and Evolving Management Approaches.

Mustafa Khalid AbdulJabbar, Susan Saab Manfi Al-Rawi, Bilal Khaleel Midhin, Roghayeh Mohammadzadeh, Raad N Hasan, Mobina Kouhzad, Nasrin Alanchari, Erta Rajabi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mustafa Khalid AbdulJabbarBiotechnology and Environmental Center, University of Fallujah, Fallujah, Iraq.
Susan Saab Manfi Al-RawiEducation Department, Anbar Education Directorate, Anbar, Iraq.
Bilal Khaleel MidhinMedical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-Maarif, Anbar, Iraq.
Roghayeh MohammadzadehDepartment of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Raad N HasanBiotechnology and Environmental Center, University of Fallujah, Fallujah, Iraq.
Mobina KouhzadDepartment of Genetics, Faculty of Science, Islamic Azad University North Tehran Branch, Tehran, Iran.
Nasrin AlanchariDepartment of Biology, Varamin Pishva, Branch, Islamic Azad University Pishva, Varamin, Iran.
Erta RajabiFaculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. ertarb@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) ranks as the third most prevalent cancer globally and poses a considerable public health challenge; concurrently, Clostridioides difficile infection (CDI) represents a significant hospital-acquired infection, with a rising incidence observed among cancer patients.

aimTo examine the relationship between CDI and CRC, it will address the risk factors associated with CDI in patients with CRC, clinical outcomes, recent findings regarding the influence of CDI on CRC, and the current strategies for management.

resultsRisk factors including gut microbiota dysbiosis, surgical interventions, chemotherapy, immunotherapy, prolonged hospitalization, and antibiotic exposure elevate susceptibility to CDI in CRC patients. Additionally, CDI correlates with more complex treatment regimens and longer hospital stays in this demographic. Furthermore, recent studies indicate that the incidence of CDI may increase the risk of CRC development.

conclusionThe prevention, diagnosis, and treatment of CDI in CRC patients are critical for enhancing outcomes. A comprehensive understanding of the bidirectional relationship between CDI and CRC can guide the development of management strategies for this important clinical issue.

Indexed as

Clostridioides difficileClostridium InfectionsColorectal NeoplasmsAnti-Bacterial AgentsGastrointestinal MicrobiomeHumansIncidenceRisk FactorsAnti-Bacterial AgentsClostridioides difficile infectionColorectal cancerDiagnosisGut microbiotaTreatment

Identifiers

PMID41085834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.