ArticleJournal of materials science. Materials in medicine2025
Biocompatible ZnO nanoflower-infused chitosan/alginate/PVA composite for accelerated skin regeneration.
Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Recent Advances and Applications of Chitin and Chitosan Hydrogel Scaffolds in Tissue Engineering.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound-healing remains a significant challenge in regenerative medicine, necessitating the development of advanced biomaterials with enhanced bioactivity and therapeutic potential. In this study, we synthesized a biocompatible zinc oxide nanoflower (ZnO NF)-infused chitosan/alginate/polyvinyl alcohol (Cs/Alg/PVA) nanocomposite for accelerated skin regeneration. ZnO NFs were synthesized via a green approach using gallic acid and ascorbic acid, yielding nanostructures with high stability and bioactive properties. The physicochemical characterization confirmed the successful formation of ZnO NFs, exhibiting a flower-like morphology. The synthesized ZnO NF-loaded Cs/Alg/PVA nanocomposite demonstrated superior swelling capacity, controlled ZnO NF release, and enhanced mechanical stability. In vitro biocompatibility studies using HDF and L929 cell lines revealed non-cytotoxic behavior and significant proliferation enhancement. Hemocompatibility assessments confirmed very minimal hemolytic activity, indicating excellent blood compatibility. In vivo, wound healing studies in a murine model demonstrated accelerated wound closure, enhanced angiogenesis, reduced inflammation, and improved collagen deposition in ZnO NF-treated groups compared to controls. Histopathological analyses further validated the superior regenerative potential of the nanocomposite. These findings highlight the promising applications of ZnO NFs-based biopolymers in advanced wound dressings, offering a multifunctional platform for tissue engineering and skin regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.