D-Serine's Journey Between Stars and Synapses.

Sarah Mountadem, Stéphane Henri Richard Oliet, Aude Panatier

Abstract readReview

In one paragraph

Review in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation.Frontiers in synaptic neuroscience · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah MountademUniv. Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000, Bordeaux, France.ORCID http://orcid.org/0000-0003-1368-7086

Stéphane Henri Richard OlietUniv. Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000, Bordeaux, France.ORCID http://orcid.org/0000-0003-0595-9029

Aude PanatierUniv. Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000, Bordeaux, France. aude.panatier@inserm.fr.ORCID http://orcid.org/0000-0002-6107-4463

Funding

Agence Nationale de la Recherche Astrocom AAPG2019Agence Nationale de la Recherche Excigly AAPG2017Agence Nationale de la Recherche, France AdAstro AAPG2021

6 · The paper itself

Abstract

Astrocytes play a pivotal role in regulating synaptic transmission, with D-serine emerging as a key gliotransmitter shaping NMDA receptor-dependent functions. This review is focusing on the multifaceted role of astrocytic D-serine from synaptic transmission to cognitive processes. While this review includes the work of other groups, it is mainly based on the findings obtained in our laboratory. Drawing from two decades of research spanning from the hypothalamus to the hippocampus, we here highlight how astrocyte-derived D-serine regulates NMDAR activity, long-term synaptic plasticity, and associated memory. Our findings have revealed the dynamic control exerted by astrocytic processes onto D-serine availability within the synaptic cleft, including the impact of the astrocytic morphological plasticity, the key role played by intracellular Ca

Indexed as

AstrocytesSerineSynapsesAnimalsHumansNeuronal PlasticityReceptors, N-Methyl-D-AspartateSynaptic TransmissionReceptors, N-Methyl-D-AspartateSerineAstrocyted-serineLong-term synaptic plasticityNMDA receptorsTripartite synapse

Identifiers

PMID41085755

DOI10.1007/s11064-025-04564-y

PMCPMC12521327

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.