Evidence map›Paper›PMID 41085745›Full record

ReviewMolecular biology reports2025

A systematic analysis of various clonal lineages of colistin-resistant Klebsiella pneumoniae with mgrB mutations.

Santosh Kumar Singh, Minakshi Gupta, Khageshwar Mahato, Shweta Shrivastava, Vijay Kant Pandey, Darshan Kumar, Jasai Mardi, Dipika Priya, Kwang-Hyun Baek, Awdhesh Kumar Mishra

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Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Santosh Kumar Singh *Department of Biotechnology, ARKA Jain University, Jamshedpur, Jharkhand, 832108, India.
Minakshi Gupta *Department of Pathology, Tata Main Hospital, Jamshedpur, Jharkhand, 831001, India.
Khageshwar MahatoDepartment of Biochemistry, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, 110029, India.
Shweta ShrivastavaSchool of Pharmacy, ARKA Jain University, Jamshedpur, Jharkhand, 832108, India.
Vijay Kant PandeyDepartment of Life Science, Netaji Subhas University, Jamshedpur, Jharkhand, India.
Darshan KumarDepartment of Biotechnology, ARKA Jain University, Jamshedpur, Jharkhand, 832108, India.
Jasai MardiDepartment of Biotechnology, ARKA Jain University, Jamshedpur, Jharkhand, 832108, India.
Dipika PriyaDepartment of Biotechnology, RKDF University, Ranchi, Jharkhand, 834004, India.
Kwang-Hyun BaekDepartment of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. khbaek@ynu.ac.kr.
Awdhesh Kumar MishraDepartment of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. awdhesh@ynu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Klebsiella pneumoniae poses a significant health threat due to their pathogenicity and high propensity to acquire resistance to wide range of antimicrobial agents. Colistin, a non-ribosomal secondary cationic amphipathic peptide, exhibits bactericidal activity. Despite its known nephrotoxic and neurotoxic effects, colistin remains in use for treating multidrug-resistant bacterial infections. However, the widespread use of colistin has led to the global emergence of colistin-resistant K. pneumoniae strains. This review investigates the global epidemiology of various clonal lineages of colistin-resistant K. pneumoniae. A comprehensive search was conducted across various databases, including PubMed, ScienceDirect, and Google Scholar. A total of 81 distinct colistin-resistant K. pneumoniae sequence types were identified worldwide, with the highest clonal diversity observed in India and China (n = 16), followed by South Korea (n = 15), Brazil (n = 14), France and Saudi Arabia (n = 12), Nigeria (n = 11), Colombia (n = 9), and Italy and Taiwan (n = 8). eBURST analysis grouped 87 colistin-resistant sequence types into 51 singletons and 9 clonal complexes, forming 5 distinct clonal groups. The findings indicate a broad global distribution of colistin-resistant K. pneumoniae clones, marked by diverse mgrB mutations. This underscores the urgent need for robust monitoring and surveillance to curb the development and dissemination of colistin-resistant K. pneumoniae and to ensure effective infection control measures.

Indexed as

Bacterial ProteinsColistinDrug Resistance, BacterialKlebsiella pneumoniaeAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialHumansKlebsiella InfectionsMicrobial Sensitivity TestsMutationAnti-Bacterial AgentsBacterial ProteinsColistinColistinEpidemiologyInsertional inactivationKlebsiella pneumoniaemgrBSequence type

Identifiers

PMID41085745

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