Evidence map›Paper›PMID 41085742›Full record

SynthesisJournal of neurology2025

Huntington's disease in MENAT: systematic review and meta-analysis of prevalence, clinical features, and genetics.

Sohaila Alshimemeri, Abdullah M Shadid, Othman Aldraihem, Naif Alsaber

Erratum issuedAbstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sohaila Alshimemeri *Neurology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. salshimemeri@ksu.edu.sa.ORCID http://orcid.org/0000-0002-2857-4511
Abdullah M Shadid *Neurology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Othman AldraihemCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Naif AlsaberDepartment of Neurology, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate prevalence and describe clinical and genetic features of Huntington's disease (HD) in the Middle East, North Africa, and Turkey (MENAT).

methodsWe conducted a PRISMA-guided systematic review and meta-analysis of EMBASE, PubMed, and Scopus from inception to October 2024. All study designs reporting HD in MENAT countries were eligible. Extracted data included demographics, clinical features, CAG repeat lengths, and prevalence. Random-effects models generated pooled estimates.

resultsSeventy-five studies (1124 individuals) were included. The pooled literature-derived prevalence was 0.17 per 100,000 (95% CI, 0.12-0.21; I

conclusionsHD appears underreported in MENAT, with prevalence far below global figures, likely reflecting underdiagnosis and limited genetic testing capacity. Priorities include expanding access to confirmatory testing, establishing national registries, and enhancing clinician awareness to improve detection, care, and regional epidemiologic precision.

Indexed as

Huntington DiseaseAfrica, NorthernHumansMiddle EastPrevalenceTurkeyEpidemiologyGenetic testingHTT geneHuntington diseaseMiddle EastPrevalence

Identifiers

PMID41085742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.