Evidence map›Paper›PMID 41085735›Full record

ArticleACS infectious diseases2025

Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections.

Mostafa A Elfawal, Victoria Banas, Bruce A Rosa, Matthew Mahoney, Emily Goetz, Paulina Chen, Raffi V Aroian, James W Janetka, Makedonka Mitreva

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mostafa A ElfawalProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.
Victoria BanasDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Bruce A RosaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-6820-446X
Matthew MahoneyDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Emily GoetzProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.
Paulina ChenProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.
Raffi V AroianProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.ORCID 0000-0002-9741-3834
James W JanetkaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-9888-5411
Makedonka MitrevaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

Funding

Function/optimization of a nematicidal Cry toxin arsenalR01AI056189 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAFFI V AROIAN · 2005 to 2026
$11.0M
Development of small molecule inhibitors of metabolic enzymes as broad spectrum anthelmintic drugsR01AI159450 · NIAID · WASHINGTON UNIVERSITY · PI JANETKA, JAMES W, MITREVA, MAKEDONKA · 2021 to 2025
$3.9M
Innovative therapeutic strategies to support elimination of river blindnessR01AI174587 · NIAID · WASHINGTON UNIVERSITY · PI James W Janetka, Sara Lustigman · 2023 to 2026
$3.2M
COMPARATIVE GENOMICS OF PARASITIC NEMATODESR01AI081803 · NIAID · WASHINGTON UNIVERSITY · PI MITREVA, MAKEDONKA · 2009 to 2018
$3.1M
Automated high throughput compound screening for broadly active anti-parasitic nematode drugsR01AI150866 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AROIAN, RAFFI V · 2020 to 2024
$2.5M
NIAID NIH HHS R01 AI056189NIAID NIH HHS R01 AI081803NIAID NIH HHS R01 AI150866NIAID NIH HHS R01 AI159450NIAID NIH HHS R01 AI174587
6 · The paper itself

Abstract

Human gastrointestinal nematodes (GINs) infect at least one billion people, mostly children, with five billion people at risk of infection. Reduced and low efficacy of currently used anthelmintics, e.g., benzimidazoles against

Indexed as

AnthelminticsProtein Kinase InhibitorsPyridazinesAncylostomaAnimalsDisease Models, AnimalFemaleHumansMiceStructure-Activity RelationshipTrichuriasisTrichurisAnthelminticsProtein Kinase InhibitorsPyridazinesanthelminticgastrointestinal nematodeshookwormPIM kinaseSGI-1776whipworm

Identifiers

PMID41085735
PMCPMC12781030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.