Evidence map›Paper›PMID 41085734›Full record

ArticleJournal of neuro-oncology2025

Identification of bone invasion as a poor prognostic factor for spinal synovial sarcoma.

Chenglong Zhao, E Zhang, Jingyu Xing, Qingmin Li, Tao Tan, Xiaomei Ma, Dongqing Zhu, Hao Zhang, Zijie Yuan, Jinbo Hu and 4 more

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Chenglong Zhao *Department of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
E Zhang *Department of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jingyu Xing *Department of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Qingmin LiDepartment of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Tao Tan *Department of Orthopedics, The 905th Hospital of the People's Liberation Army Navy, Naval Medical University, Shanghai, China.
Xiaomei MaDepartment of Pathology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Dongqing ZhuDepartment of Radiology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Hao ZhangDepartment of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Zijie YuanDepartment of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jinbo HuDepartment of Orthopedics, The 905th Hospital of the People's Liberation Army Navy, Naval Medical University, Shanghai, China.
Wenlan ZhiDepartment of Orthopedics, The 905th Hospital of the People's Liberation Army Navy, Naval Medical University, Shanghai, China.
Haifeng WeiDepartment of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China. weihfspine@163.com.
Jianru XiaoDepartment of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China. cz_xiaojianru@163.com.
Cheng YangDepartment of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China. ddyc2001@163.com.

Funding

National Natural Science Foundation of China 82372910Science and Technology Commission of Shanghai Municipality 24SF1904600Shanghai Municipal Health and Family Planning Commission 201840209
6 · The paper itself

Abstract

purposeSynovial sarcoma (SS) is a rare soft-tissue malignancy, with spinal involvement being exceptionally uncommon and associated with poor prognosis. Due to limited data, prognostic factors for spinal SS remain unclear. This study aimed to analyze clinical outcomes and identify prognostic indicators in spinal SS.

methodsWe conducted a retrospective review of 46 SS patients (36 spinal, 10 extremity) treated at our center (2010–2022). Clinical, radiological, and pathological data were analyzed. Treatment strategies included surgical resection (en-bloc where feasible), chemotherapy, and radiotherapy. Bone invasion was assessed via imaging. Prognostic factors for progression-free survival (PFS) and overall survival (OS) were evaluated using Cox regression and Kaplan-Meier analysis.

resultsSpinal SS exhibited frequent bone invasion (25/36 cases), a feature rare in extremity SS. The 5-year PFS and OS rates were 33.2% and 35.4%, respectively. Multivariate analysis identified sex(HR 9.81, p = 0.009), bone invasion (HR 20.79, p = 0.003) and Ki-67 ≥ 30% (HR 18.77, p < 0.001) as independent predictors of poor OS. For PFS, prior radiotherapy (HR 4.05, p = 0.017) and Ki-67 ≥ 30% (HR 4.63, p = 0.012) were significant. En-bloc resection improved OS (p = 0.028) but not PFS (p = 0.161). Radiotherapy-naïve patients showed better PFS than pre-irradiated cases.

conclusionSpinal SS demonstrates aggressive behavior, with bone invasion as a potential novel, independent poor prognostic factor. High Ki-67 and prior radiotherapy also predict worse outcomes. En-bloc resection should be prioritized when feasible. These findings highlight the need for tailored management strategies in spinal SS.

Indexed as

Bone NeoplasmsSarcoma, SynovialSpinal NeoplasmsAdolescentAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessPrognosisRetrospective StudiesSurvival RateYoung AdultBone invasionPrognostic factorsSpinal tumorsSurvival analysisSynovial sarcoma

Identifiers

PMID41085734

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