Evidence map›Paper›PMID 41085722›Full record

ArticleJournal of molecular histology2025

Oxytocin receptor expression in developing mouse gonads and its modulation by high-dose folic acid.

Hakan Sahin, Fidan Pashayeva, Gozde Erkanli Senturk

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Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Hakan Sahin *Department of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, 34098, Turkey.
Fidan Pashayeva *Department of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, 34098, Turkey.
Gozde Erkanli SenturkDepartment of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, 34098, Turkey. gozde.erkanlisenturk@iuc.edu.tr.

Funding

Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa 36930
6 · The paper itself

Abstract

The oxytocin receptor (OTR) is known to be expressed in various organs, including the adult reproductive system. However, its expression in developing gonads has not yet been reported. This study investigates OTR expression in the ovaries and testes during critical developmental stages, specifically embryonic day 13.5 (E13.5), embryonic day 18.5 (E18.5), and postnatal day 14 (P14). According to our findings, both developing ovaries and testes exhibited OTR expression, including in immature follicle and Sertoli cells. OTR-expressing cells increased in the developing ovary, while a decrease was observed in the postnatal testis. In addition, our results showed that a high dose folic acid (FA) diet affected the number of OTR-expressing cells in developing gonads, particularly during the later stages of embryogenesis. These findings suggest that OTR may play a role in gonadal development and that its expression is influenced by sex. Furthermore, changes in folic acid supplementation may interfere with this developmental process.

Indexed as

Folic AcidGene Expression Regulation, DevelopmentalGonadsOvaryReceptors, OxytocinTestisAnimalsFemaleMaleMiceFolic AcidReceptors, OxytocinDevelopmentFolic acidFollicle cellsOvaryOxytocin receptorSertoli cellsTestis

Identifiers

PMID41085722

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.