Evidence map›Paper›PMID 41085662›Full record

ArticlePsychopharmacology2026

Adenosine A

Naoya Nishitani, Katsuyuki Kaneda

Abstract read
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In one paragraph

Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Naoya NishitaniLaboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
Katsuyuki KanedaLaboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan. k-kaneda@p.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0001-7046-9275

Funding

Japan Society for the Promotion of Science 22K15290, 25K10000Japan Society for the Promotion of Science 23K27484, 23K18419, 21K18548Smoking Research Foundation Smoking Research FoundationTakeda Science Foundation Takeda Science Foundation
6 · The paper itself

Abstract

rationaleWheel running is a highly motivated behavior in rodents and is often used as a natural reinforcer. The adenosine A

objectivesThis study aimed to investigate how systemic and intra-NAc pharmacological manipulation of A

methodsWe examined the effects of systemic administration of the A

resultsSystemic istradefylline administration increased voluntary wheel-running activity and general locomotion. In contrast, CGS21680 decreased voluntary wheel-running without affecting locomotion. In the operant task, systemic CGS21680 significantly reduced the operant response, a measure of appetitive behavior, without altering running duration, which reflects consummatory behavior. Similarly, intra-NAc infusion of CGS21680 suppressed appetitive behavior.

conclusionsThese findings demonstrate that, in male mice, A

Indexed as

MotivationMotor ActivityNucleus AccumbensReceptor, Adenosine A2ARunningAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsAnimalsConditioning, OperantMaleMiceMice, Inbred C57BLPhenethylaminesPurinesReward2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsistradefyllinePhenethylaminesPurinesReceptor, Adenosine A2AAdenosine A2A receptorBehavioral addictionMotivationNucleus accumbensOperant conditioningWheel running

Identifiers

PMID41085662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.