Ascending Aorta-Descending Aorta Outer/Internal Distance Index as a Potential Novel Method for Predicting Fetal Complete Transposition of the Great Arteries: A Pilot Study.

Qi Yang, Yanping Ruan, Xiaoyan Gu, Ye Zhang, Xiaowei Liu, Lin Sun, Ying Zhao, Yihua He, Jiancheng Han

Abstract read

In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Qi YangEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Yanping RuanEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Xiaoyan GuEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Ye ZhangEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Xiaowei LiuEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Lin SunEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Ying ZhaoEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Yihua HeEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. heyihuaecho@hotmail.com.

Jiancheng HanEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. han_jc1977@hotmail.com.

Funding

Beijing Natural Science Foundation L222152

6 · The paper itself

Abstract

To investigate the ascending aorta (AAO)-descending aorta (DAO) outer/internal distance index (AAO-DAO ODI/IDI) prediction value for fetal complete transposition of the great arteries (D-TGA). Selected D-TGA fetuses between January 2019 and June 2024 as the D-TGA group and an equal number of normal fetuses (gestational age (GA) matched ± 1 week) as the control group. The AAO-DAO outer/internal distance (AAO-DAO OD/ID) and DAO diameter were measured in the aortic arch long-axis view, and the AAO-DAO ODI/IDI were calculated, which are the ratios of AAO-DAO OD/ID to DAO. The relationship between AAO-DAO OD/ID and AAO-DAO ODI/IDI and GA of the normal group was analyzed. The differences in AAO-DAO ODI/IDI between the D-TGA and the normal fetuses were compared, and the difference between the D-TGA with intact ventricular septum (D-TGA-IVS) and the D-TGA with ventricular septal defects (D-TGA-VSD) was compared. The sensitivity and specificity of the receiver operating characteristic (ROC) curve were applied to analyze the discrimination ability of AAO-DAO ODI/IDI for D-TGA and normal fetuses and D-TGA-IVS and D-TGA-VSD. In the normal control group, the DOA ICC was 0.972 (95% CI 0.958-0.982), the AAO-DAO OD ICC was 0.988 (95% CI 0.983-0.992), and the AAO-DAO ID ICC was 0.978 (95% CI 0.967-0.985); in the D-TDA group, the DAO ICC was 0.975 (95% CI 0.956-0.989), the AAO-DAO OD ICC was 0.994 (95% CI 0.991-0.996), and the AAO-DAO ID ICC was 0.991 (95% CI 0.987-0.994). The AAO-DAO OD (r = 0.811, P < 0.001) and AAO-DAO ID (r = 0.707, P < 0.001) increased with increasing GA. The linear regression equations are AAO-DAO OD = 0.087*GA-0.474 (R

Indexed as

AortaAorta, ThoracicTransposition of Great VesselsUltrasonography, PrenatalFemaleGestational AgeHumansPilot ProjectsPredictive Value of TestsPregnancyAscending aorta–descending aorta outer/internal distanceAscending aorta–descending aorta outer/internal distance indexComplete transposition of the great arteriesFetal echocardiography

Identifiers

PMID41085650

DOI10.1007/s00246-025-04064-4

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.