ArticleMolecular biotechnology2026
The Anti-atopic Perilla Seed Oil and Ethanol Extract on TNF-α/IFN-γ-Stimulated inflammatory Responses in Human HaCaT Keratinocytes.
Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Multi-Kingdom Synergy ofLife (Basel, Switzerland) · 2026Review
- Mandelamide Isolated fromBiomolecules · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic inflammatory atopic dermatitis (AD) is a skin disorder characterized by cutaneous inflammation and a dysfunctional skin barrier. Although perilla seed oil (PO) is known to exhibit various biological activities, including anti-cancer, anti-inflammatory, and anti-oxidant effects, its inhibitory effects together with the ethanol extract of PO (PE) on atopic and inflammatory responses in the dermal skin has not yet been investigated. In the present study, PE significantly reduced mRNA expressions of inflammation-associated cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β, IL-6, IL-8, and IL-33. Furthermore, PE decreased the levels of the chemokine, thymus- and activation-regulated chemokine (TARC/CCL17) in TNF-α and interferon (IFN)-γ-stimulated human HaCaT keratinocytes. In addition, PE effectively suppressed activation of MAPK/NF-κB and JAK/STAT signaling pathways in HaCaT keratinocytes co-stimulated with TNF-α and IFN-γ. These findings indicate that PE possesses anti-inflammatory and anti-atopic properties, suggesting its potential benefits in treating inflammatory skin diseases including AD.
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Registered trials
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