Evidence map›Paper›PMID 41085614›Full record

ArticleClinical transplantation2025

Twenty-Year Kidney Transplant Outcomes With Prednisone-Free Maintenance Immunosuppression: A Matched Control Analysis.

Lindsey Turner, David M Vock, Erika Helgeson, Raja Kandaswamy, Richard Spong, Timothy Pruett, Erik Finger, Vanessa Humphreville, Srinath Chinnakotla, Andrew Adams and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lindsey TurnerDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
David M VockDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Erika HelgesonDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Raja KandaswamyDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Richard SpongDivision of Nephrology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Timothy PruettDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Erik FingerDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-3899-6985
Vanessa HumphrevilleDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Srinath ChinnakotlaDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-5443-1258
Andrew AdamsDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Rasha El-RifaiDivision of Nephrology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Karthik RamanathanDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Arthur J MatasDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-9957-639X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been concern about long-term outcomes of kidney transplant recipients treated with prednisone-free maintenance immunosuppression. We studied 20-year outcomes for recipients treated with discontinuation of prednisone <1 week posttransplant (rapid discontinuation of prednisone [RDP]) compared with contemporaneous matched controls treated with maintenance prednisone (MP). First and second, adult living donor (LD) and deceased donor (DD) kidney transplant recipients from 1999 to 2009, treated with RDP were matched-using data from the Scientific Registry of Transplant Recipients-with contemporaneous controls, from large transplant centers, who were treated with MP. A total of 361 DD recipients treated with RDP were matched with 1805 treated with long-term MP. A total of 763 LD recipients treated with RDP were matched with 2289 treated with long-term MP. DD recipients treated with RDP had significantly better recipient survival (p = 0.02); there was no difference in graft or death-censored graft survival. For LD recipients, there was no difference between groups for all outcomes. Kidney transplant recipients treated with RDP had better or similar long-term outcomes as those treated with long-term MP. RDP should be considered for the majority of kidney transplant recipients.

Indexed as

Graft RejectionGraft SurvivalImmunosuppressive AgentsKidney Failure, ChronicKidney TransplantationPostoperative ComplicationsPrednisoneAdultCase-Control StudiesFemaleFollow-Up StudiesGlomerular Filtration RateHumansKidney Function TestsMaleMiddle AgedImmunosuppressive AgentsPrednisonedonors and donationimmunosuppressantkidney transplantation

Identifiers

PMID41085614
PMCPMC12520163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.