ArticleArchives of microbiology2025
Pediococcus pentosaceus strain SPARC2 as a potential probiotic food supplement: genomic insight, probiotic potential, and biosafety profiling in BALB/c mice.
Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Multi-Omics Analysis Reveals the Gut-Mediated Mechanism Underlying the Seasonal Non-Laying Phenotype in Zhedong White Geese (Animals : an open access journal from MDPI · 2026Article
- Multi-Strain Probiotic Intervention Modestly Modulates Microbial Composition and Inflammatory Profile in Individuals with Long COVID.Microorganisms · 2026Article
- Genomic Characterization, Safety Assessment, and Probiotic Potential of a Novel Human-DerivedMicroorganisms · 2026Article
- Integrative metagenomic and metabolomic analysis reveals a gut microbiota-metabolite-immune axis in pediatric allergic rhinitis with functional constipation.Frontiers in cellular and infection microbiology · 2026Article
- Evaluation of probiotic properties and genome analysis of the newFrontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediococcus pentosaceus species is an emerging probiotic that has recently gained great experimental interest worldwide. This study assessed the probiotic properties, genetic potential, and safety aspects of gut-associated P. pentosaceus for prospective application in animal feed. The in vitro investigation of the P. pentosaceus strain SPARC2 isolated from Nilli Ravi buffaloes gut showed favourable enzymatic (proteolytic, lipolytic, and amylolytic) and antagonistic activities against indicator bacterial strains. Furthermore, strain SPARC2 demonstrated non-toxic and non-hemolytic properties and susceptibility to several tested antibiotics, suggesting its safety for animal consumption. Genome-level analysis revealed that the strains SPARC2 carry no virulence or resistance genes, while numerous probiotic potential genes were detected in the P. pentosaceus SPARC2 genome. The in vivo safety investigation of SPARC2 demonstrated no physiological or haematological dysfunctions in mice. No expression of tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-1β) cytokines was observed in the colon tissue of mice. Moreover, P. pentosaceus SPARC2 (1 × 10
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Registered trials
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