ArticleJournal of neuro-oncology2025
Cognitive impact of repeated surgical resections for the management of high-grade glioma.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeHigh-grade gliomas (HGG) are aggressive primary brain tumors associated with substantial neurological and functional morbidity. While previous research has shown no significant differences in self-reported quality of life between patients undergoing first-time resection (FTR) and those undergoing repeat surgical resection (RSR), the impact of repeated surgical resections on objective cognitive outcomes remains unclear. This study compared pre- and postoperative neuropsychological performance in these two patient groups.
methodsSixty-seven adults with HGG (FTR: n = 39; RSR: n = 28) completed comprehensive neuropsychological evaluations both pre- and approximately 2 weeks postoperatively. Cognitive domains assessed included attention/working memory, processing speed, executive functioning, language, and learning/memory. Standardized Z-scores were used to compute composite domain scores, and both composite-score and individual-test approaches were applied to classify cognitive impairment and postoperative decline.
resultsThere were no group differences in any of the cognitive domains at baseline. Four to 28% of the surgical sample showed single domain cognitive impairment while 33 to 71% showed multidomain impairment depending on the classification method used. Further, no significant differences were seen between the FTR and RSR groups in cognitive outcome or change following surgery. Most patients showed no decline in cognitive performance. Across classification schemes, 18 to 36% declined in a single domain and 4 to 26% declined in multiple domains.
conclusionsIn a carefully selected, high-functioning surgical cohort, repeat surgical resection was not associated with increased risk of early postoperative cognitive decline compared to first-time resection. These findings support the consideration of RSR as a viable treatment option for recurrent HGG when aiming to balance oncologic control with preservation of cognitive function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.