Evidence map›Paper›PMID 41085520›Full record

ArticleNeurodegenerative disease management2026

Immune system modifications in atypical parkinsonism related to autoimmunity - a case control study.

Annamma Mathai, Sudheeran Kannoth, Vivek Nambiar, Siby Gopinath, Meena Thevarkalam, Anandkumar Anandakuttan, Sugavanan Kalingavarman, Ullas Mony, Manu Raj, Renjitha Bhaskaran

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Article in Neurodegenerative disease management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Annamma MathaiNeuroimmunology Laboratory, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Sudheeran KannothNeuroimmunology Laboratory, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Vivek NambiarDepartment of neurology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Siby GopinathDepartment of neurology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Meena ThevarkalamNeuroimmunology Laboratory, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Anandkumar AnandakuttanDepartment of neurology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Sugavanan KalingavarmanAmrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Ullas MonyAmrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Manu RajDepartment of Health Science Research, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.
Renjitha BhaskaranDepartment of Biostatistics, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammation is known in atypical parkinsonism (AP), but the role of autoimmunity is unclear. This study evaluates immune system modifications suggesting autoimmunity in AP.

methodsIncluded patients with AP diagnosed at Amrita Institute of Medical Sciences, Kochi (December 2018-May 2019), and age- and sex-matched controls. Fifteen immune parameters, including T regulatory cells, RORγt, and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, IL-21, IL-22, IL-23, TNF, IFN-γ, GM-CSF, NF-κB, TGF-β), were assessed in peripheral blood (flow cytometry and ELISA).

resultsTwenty-six cases (mean age 67.8 ± 7.5 years; 16 males) and 15 controls (mean age 68.1 ± 3.5 years; 10 males) studied. Diagnoses included progressive supranuclear palsy (

conclusionsElevated RORγt and cytokines suggest immune dysregulation and possible autoimmune mechanisms in AP, warranting further investigation.

Indexed as

AutoimmunityCytokinesParkinsonian DisordersAgedCase-Control StudiesFemaleHumansMaleMiddle AgedCytokinesAlzheimer’s diseasebiomarkersparkinsonismparkinson’s diseaseProgressive supranuclear palsy

Identifiers

PMID41085520
PMCPMC13390528

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