SynthesisAging2025
Hospitalization with infections and risk of Dementia: a systematic review and meta-analysis.
Synthesis in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association Between Respiratory Vaccines and Risk of Cognitive Impairment, Dementia and Alzheimer's Disease: A Scoping Review.Vaccines · 2026Review
- Long-term risk of dementia following encephalitis: a large-scale retrospective cohort study of electronic health records.Journal of neurology · 2026Article
- Challenge-based ex vivo immune profiling reveals stimulus-dependent peripheral immune reprogramming in Alzheimer's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDementia affects more than 50 million people worldwide, with 10 million new diagnosis each year. The link between hospitalization with infections and risk of Dementia is unclear. We conducted a meta-analysis on the association between hospitalization with infection and risk of Dementia.
methodsWe searched MEDLINE and Embase from inception to March 31, 2025 to identify cohort studies comparing the frequency of Dementia in patients hospitalized with infections with those without. We computed hazard ratios (HR) for each study and pooled the results using a random-effects meta-analysis.
resultsOut of 1900 studies that were screened initially, 16 studies comprising 4,266,276 patients were included for analysis. Hospitalization with infection was associated with an increased risk of all-cause Dementia (HR: 1.83, 95% CI: 1.58-2.13,
conclusionsOur meta-analysis showed that hospitalization with infection was associated with increased risk of Dementia. Sepsis carried the highest risk, followed by Pneumonia, Urinary Tract Infections, Skin and Soft Tissue infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.