Evidence map›Paper›PMID 41085278›Full record

ArticleJournal of virology2025

Nephropathogenic infectious bronchitis virus induces epithelial-mesenchymal transition of renal tubular epithelial cells through the TGF-β/p-P38 pathway causing uric acid excretion disorder in chickens.

Yunfeng Chen, Yan Shi, Cheng Huang, Haoyu Huang, Yizhou Zeng, Gaofeng Cai, Zhanhong Zheng, Ping Liu, Xiaona Gao, Xiaoquan Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yunfeng ChenJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.ORCID 0009-0002-4037-2848
Yan ShiSchool of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Cheng HuangJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Haoyu HuangJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Yizhou ZengJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Gaofeng CaiJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Zhanhong ZhengJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Ping LiuJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Xiaona GaoJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Xiaoquan GuoJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.ORCID 0009-0008-9115-246X

Funding

Jiangxi Province Natural Science Foundation No. 20232ACB205013National Natural Science Foundation of China No.32072935National Natural Science Foundation of China No.32360906
6 · The paper itself

Abstract

Nephropathogenic infectious bronchitis virus (NIBV) infection usually causes kidney enlargement and urate deposition in chickens, leading to sudden death. However, the mechanism by which NIBV causes urate deposition in the kidneys has not yet been elucidated. The coordinated operation of uric acid transporters is crucial for the kidneys to maintain uric acid homeostasis, and existing studies have shown that the occurrence of cell epithelial-mesenchymal transition (EMT) can affect the expression of uric acid transporters. Thus, this study aimed to explore the effect of NIBV on urate transporters and elucidate the mechanism of EMT in NIBV-induced urate deposition in chicken kidneys

Indexed as

Coronavirus InfectionsEpithelial CellsEpithelial-Mesenchymal TransitionInfectious bronchitis virusKidney Tubulesp38 Mitogen-Activated Protein KinasesPoultry DiseasesTransforming Growth Factor betaUric AcidAnimalsATP Binding Cassette Transporter, Subfamily G, Member 2Cell LineChickensKidneyATP Binding Cassette Transporter, Subfamily G, Member 2p38 Mitogen-Activated Protein KinasesTransforming Growth Factor betaUric AcidABCG2EMTNIBVTGF-β/p-p38 pathwayuric acid

Identifiers

PMID41085278
PMCPMC12645968

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.