ArticleJournal of the American Heart Association2025
Blood Pressure Variability as a Diagnostic Marker for α-Synucleinopathy in Patients With Orthostasis.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Circadian control of immune homeostasis in cardiovascular health and disease.Frontiers in immunology · 2026Review
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10 authors.
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Abstract
backgroundIt is widely accepted that patients with α-synucleinopathy show large blood pressure (BP) variability. We aimed to investigate the diagnostic utility of ambulatory BP monitoring in detecting α-synucleinopathy in patients with orthostasis.
methodsWe prospectively recruited consecutive patients with orthostatic dizziness between December 2021 and February 2024 at the Dizziness Center of a tertiary referral-based hospital in South Korea. All patients underwent a detailed examination using Frenzel goggles and systematic extrapyramidal neurologic examination for eligibility. All patients underwent 24-hour noninvasive ambulatory BP monitoring and head-up tilt table test using a Finometer.
resultsAmong the 223 patients, 22 (10%) were finally diagnosed with α-synucleinopathy. The diagnosis could have been made with emergence of motor symptoms 1 to 3 years after the presentation in 5 (22%) of the 22 patients. The coefficient of variance of systolic BP (SBP;
conclusionsOur findings implicate that ambulatory BP monitoring can help detect α-synucleinopathy in patients with orthostasis. Large BP variability and loss of circadian BP rhythm during ambulatory BP monitoring can serve as early warning signs of α-synucleinopathy, even before the prominent manifestation of motor symptoms.
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