Evidence map›Paper›PMID 41085158›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers.

D Luke Fischer, Lea T Grinberg, Jared T Ahrendsen, Thomas G Beach, Kevin F Bieniek, Rudolph J Castellani, Rati Chkheidze, Inma Cobos, Mark Cohen, John F Crary and 36 more

Abstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

D Luke FischerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-5245-3832
Lea T GrinbergDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.
Jared T AhrendsenDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Thomas G BeachCivin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, USA.
Kevin F BieniekDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Rudolph J CastellaniDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Rati ChkheidzeDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Inma CobosDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Mark CohenDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
John F CraryDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Dennis W DicksonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.
Brittany N DuggerDepartment of Pathology and Laboratory Medicine, University of California Davis, Sacramento, California, USA.
Sara R DunlopDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Kurt FarrellDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Mohammad HaeriDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
William HarrisonDepartment of Pathology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, North Carolina, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California Irvine, 1111 Gillespie Neuroscience Research Facility, Irvine, California, USA.
Annie HinikerDepartment of Pathology, University of Southern California, Los Angeles, California, USA.
Eric J HuangDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Anita HuttnerDepartment of Pathology, Yale University, New Haven, Connecticut, USA.
Pouya JamshidiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Alifiya KapasiDepartment of Pathology, Rush University Medical Center, Chicago, Illinois, USA.
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Julia KoflerDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Caitlin S LatimerDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Ann C McKeeDepartments of Neurology and Pathology and Laboratory Medicine, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA.
Karin MenteDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Michael B MillerDepartment of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Thomas J MontineDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Meaghan MorrisDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Melissa E MurrayDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.
Peter T NelsonDivision of Neuropathology, Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA.
Kathy L NewellDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Richard J PerrinDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Biswarathan RamaniDepartment of Pathology, University of California San Francisco, San Francisco, California, USA.
R Ross ReichardDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Subhojit RoyDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Johannes C M SchlachetzkiDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
William W SeeleyMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Geidy E SerranoCivin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, USA.
Salvatore SpinaMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Andrew F TeichDepartment of Pathology and Cell Biology and Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.
Shih-Hsiu J WangDepartment of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Thomas WisniewskiCenter for Cognitive Neurology, Departments of Pathology, Neurology, and Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.
Edward B LeeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MICHAEL W WEINER · 2016 to 2026
$226.7M
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9M
Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, JOSEPH HYUNGWOO · 2020 to 2025
$103.7M
Functionally guided adult whole brain cell atlas in human and NHPUM1MH130981 · NIMH · ALLEN INSTITUTE · PI Ed Lein, Hongkui Zeng · 2022 to 2026
$91.9M
ADRC Consortium for Clarity in ADRD Research Through ImagingU01AG082350 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sarah Biber, BRADFORD C DICKERSON · 2023 to 2026
$90.0M
Topographic, cell type and molecular pathway characterization ofAlzheimer's disease using single cell transcriptomics and epigenomicsU19AG060909 · NIA · ALLEN INSTITUTE · PI Jennie Leigh Close, Michael Hawrylycz · 2020 to 2026
$83.6M
DIAN-TU: Tau Next Generation Prevention Trial - Administrative SupplementR01AG068319 · NIA · WASHINGTON UNIVERSITY · PI RANDALL J BATEMAN · 2020 to 2026
$81.4M
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
10,000 Brains NeuroAI IncAllen Institute for Brain ScienceAlzheimer's AssociationAlzheimer's Association Florida Gulf Coast SG-25-1416824Barrist Family FoundationBluefield Project to Cure FTDChan Zuckerberg Initiative 2024-351073CurePSP 685-2023-06DeCrane Family Fund for PPA ResearchKaren Strauss Cook Research Scholar AwardNancy and Buster Alvord EndowmentNIA NIH HHS DP2 AG086138NIA NIH HHS K01 AG070326NIA NIH HHS K01 AG075177NIA NIH HHS K24 AG053435NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG066597NIA NIH HHS P01 AG084497NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG072980NIA NIH HHS P30 AG086401NIA NIH HHS P30 AG086404NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG053267NIA NIH HHS R01 AG054008NIA NIH HHS R01 AG060477NIA NIH HHS R01 AG060942NIA NIH HHS R01 AG062348NIA NIH HHS R01 AG062517NIA NIH HHS R01 AG064314NIA NIH HHS R01 AG065341NIA NIH HHS R01 AG068319NIA NIH HHS R01 AG069912NIA NIH HHS R01 AG075802NIA NIH HHS R01 AG077422NIA NIH HHS R01 AG079280NIA NIH HHS R01 AG080585NIA NIH HHS R01 AG082346NIA NIH HHS R01 AG082730NIA NIH HHS R01 AG087226NIA NIH HHS R01 AG087280NIA NIH HHS R01 AG088656NIA NIH HHS R01 AG090551NIA NIH HHS R13 AG059336NIA NIH HHS R24 AG073137NIA NIH HHS R24 AG073199NIA NIH HHS R56 AG057195NIA NIH HHS RF1 AG062348NIA NIH HHS RF1 AG065341NIA NIH HHS U01 AG057195NIA NIH HHS U01 AG082350NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG032438NIA NIH HHS U19 AG060909NIA NIH HHS U19 AG063911NIA NIH HHS U19 AG066567NIA NIH HHS U19 AG068054NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG072458NIH HHS DP2AG086138NIH HHS K01AG070326NIH HHS P01AG003991NIH HHS P01AG019724NIH HHS P01AG066597NIH HHS P01AG084497NIH HHS P20AG068082NIH HHS P30AG019610NIH HHS P30AG062421NIH HHS P30AG062422NIH HHS P30AG062429NIH HHS P30AG062677NIH HHS P30AG062715NIH HHS P30AG066444NIH HHS P30AG066462NIH HHS P30AG066468NIH HHS P30AG066506NIH HHS P30AG066507NIH HHS P30AG066508NIH HHS P30AG066509NIH HHS P30AG066511NIH HHS P30AG066512NIH HHS P30AG066514NIH HHS P30AG066515NIH HHS P30AG066518NIH HHS P30AG066519NIH HHS P30AG066530NIH HHS P30AG066546NIH HHS P30AG072931NIH HHS P30AG072946NIH HHS P30AG072947NIH HHS P30AG072958NIH HHS P30AG072959NIH HHS P30AG072972NIH HHS P30AG072973NIH HHS P30AG072975NIH HHS P30AG072976NIH HHS P30AG072977NIH HHS P30AG072978NIH HHS P30AG072979NIH HHS P30AG072980NIH HHS P30AG079280NIH HHS P30AG086401NIH HHS P30AG086404NIH HHS P50AG023501NIH HHS R01AG053267NIH HHS R01AG054008NIH HHS R01AG060942NIH HHS R01AG062348NIH HHS R01AG062517NIH HHS R01AG068319NIH HHS R01AG069912NIH HHS R01AG075802NIH HHS R01AG077422NIH HHS R01AG080585NIH HHS R01AG082346NIH HHS R01AG082730NIH HHS R01AG087226NIH HHS R01AG087280NIH HHS R01AG088656NIH HHS R01AG090551NIH HHS R01MH116046NIH HHS R01NS095252NIH HHS R01NS111978NIH HHS R01NS129609NIH HHS R13AG059336NIH HHS R24AG073137NIH HHS R24AG073199NIH HHS RF1AG065341NIH HHS RF1NS128908NIH HHS U01AG057195NIH HHS U01AG082350NIH HHS U01NS137484NIH HHS U01NS137500NIH HHS U01OH012486NIH HHS U19AG024904NIH HHS U19AG032438NIH HHS U19AG060909NIH HHS U19AG063911NIH HHS U19AG066567NIH HHS U19AG068054NIH HHS U24AG072458NIH HHS U24NS133945NIH HHS U24NS133949NIH HHS U24NS135568NIH HHS U24NS135651NIH HHS UE5NS070680NIH HHS UF1NS120463NIH HHS UM1MH130981NIH HHS UM1MH134812NIMH NIH HHS R01 MH116046NIMH NIH HHS UM1 MH130981NIMH NIH HHS UM1 MH134812NINDS NIH HHS R01 NS095252NINDS NIH HHS R01 NS111978NINDS NIH HHS R01 NS129609NINDS NIH HHS RF1 NS128908NINDS NIH HHS U01 NS137484NINDS NIH HHS U01 NS137500NINDS NIH HHS U24 NS133945NINDS NIH HHS U24 NS133949NINDS NIH HHS U24 NS135568NINDS NIH HHS UE5 NS070680NIOSH CDC HHS U01 OH012486Rainwater Charitable TrustRainwater Charitable Trust/Tau ConsortiumShanahan Family FoundationSilicon Valley Community FoundationStuart Katz and Dr. Jane MartinThe Fred and Barbara Erb Family FoundationU.S. Department of Defense W81XWH-21-S-TBIPH2
6 · The paper itself

Abstract

Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for neurodegeneration research. Neuropathology has championed the key principles of proteinopathy, selective vulnerability, and stereotypic spread. Furthermore, neuropathologic studies advanced our understanding of ADRD prevalence, heterogeneity, clinical-pathological correlations, and genetic underpinnings, spurring biomarker development for target engagement and disease monitoring. Disease-modifying therapies for AD were inspired and informed by neuropathology. The neuropathology community is poised to refine diagnostics, leveraging digital pathology and integrating genetics and pathomics to enhance subtyping for novel precision medicine approaches. Despite some common misconceptions and logistical challenges, neuropathology continues to be a critical component of the ADRD research infrastructure, serving as a key bridge between allied basic and clinical sciences. HIGHLIGHTS: We celebrate 40 years of NIA-funded ADRCs and their contributions through neuropathology studies that have significantly advanced our understanding and treatment of ADRD. Neuropathology uncovers principles of neurodegenerative disease: proteinopathy, selective vulnerability, and stereotypic spread, informing diagnostics and therapies. Development of AD biomarkers with reference to neuropathology enhances accuracy in diagnosis and monitoring, paving the way for targeted disease-modifying therapies. Integration of digital pathology, genetics, and novel tools in neurodegeneration research promises advanced precision medicine approaches and refined diagnostics. Misconceptions and logistical challenges to neuropathological research are addressed to improve understanding and collaboration.

Indexed as

Alzheimer DiseaseBiomedical ResearchNeuropathologyHistory, 20th CenturyHistory, 21st CenturyHumansNational Institute on Aging (U.S.)United StatesAlzheimer diseasedementianeurodegenerative diseasesneuropathologypathomics

Identifiers

PMID41085158
PMCPMC12519528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.