Evidence map›Paper›PMID 41085136›Full record

ArticlePacing and clinical electrophysiology : PACE2025

Mortality Trends in Atrial Fibrillation With Cardiomyopathy Among Patients Aged 25 and Older in the United States.

Muhammad Abdullah Naveed, Sivaram Neppala, Ahila Ali, Muhammad Omer Rehan, Hamza Naveed, Rabia Iqbal, Bazil Azeem, Mushood Ahmed, Muhammad Zia Khan, Siddharth Agarwal and 5 more

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Article in Pacing and clinical electrophysiology : PACE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Muhammad Abdullah NaveedDepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.ORCID 0009-0006-9230-6569
Sivaram NeppalaDivision of Cardiology, The University of Texas Health Sciences Center, San Antonio, Texas, USA.ORCID 0009-0008-8182-1260
Ahila AliDepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.ORCID 0009-0003-1176-7928
Muhammad Omer RehanDepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Hamza NaveedDepartment of Internal Medicine, Queen Elizabeth the Queen Mother Hospital, EKHUFT, Margate, Kent, UK.
Rabia IqbalDepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Bazil AzeemDepartment of Cardiology, Shaheed Muhtarma Benazir Bhutto Liyari Medical College, Karachi, Pakistan.ORCID 0009-0002-5284-876X
Mushood AhmedDepartment of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.ORCID 0000-0001-9872-8224
Muhammad Zia KhanDivision of Cardiology, Deborah Heart and Lung Center, Brown Mills, New Jersey, USA.
Siddharth AgarwalDepartment of Cardiology, Mayo Clinic, Rochester, Minnesota, USA.
Himaja Dutt ChigurupatiDepartment of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, New Jersey, USA.ORCID 0000-0003-3885-8515
Nimra ShafiDepartment of Medicine, Arnot Ogden Medical Center, Elmira, New York, USA.
Yasir SattarDepartment of Interventional Cardiology, West Virginia University, Morgantown, West Virginia, USA.
Zain Ul Abideen AsadDivision of Cardiology, University of Oklahoma, Oklahoma City, Oklahoma, USA.
Muhammad Bilal MunirSection of Electrophysiology, Division of Cardiology, University of California, Davis, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is a prevalent arrhythmia that frequently coexists with cardiomyopathy, leading to deteriorated cardiovascular outcomes. Analyzing the trends associated with these conditions is essential for improving prevention strategies and management practices.

methodsCDC WONDER (1999-2023) data were analyzed to assess AF with cardiomyopathy-related mortality in patients aged ≥ 25. Using Joinpoint regression analysis, we calculated age-adjusted mortality rates (AAMRs) per 100,000 patients and average annual percentage changes (AAPCs) to analyze mortality trends.

resultsAF with cardiomyopathy is responsible for 126,377 deaths among adults aged 25 and older. Alarmingly, AAMRs have surged from 1.8 per 100,000 in 1999 to 3.0 in 2023 (AAPC: 2.11, p < 0.001). The upward trend remains pronounced, particularly between 2016 and 2021, with an annual percentage change of 6.17 (p = 0.02). Disparities in mortality rates are striking. Men face a higher AAMR than women (3.1 vs. 1.5), and Black individuals bear the heaviest burden at 2.4, closely followed by Whites at 2.3. Regionally, Vermont stands out with the highest AAMR at 3.6, while New York reports the lowest at 1.3. Both rural and urban areas maintain equal AAMRs of 2.1, yet the increase in rural regions is particularly concerning, reflecting an AAPC of 2.44 compared to 1.78 in urban settings.

conclusionThe rising mortality rates from AF with cardiomyopathy in patients, particularly among men, Black individuals, and rural residents, demand urgent action. These concerning trends underscore a public health crisis that must be addressed.

Indexed as

Atrial FibrillationCardiomyopathiesAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedUnited Statesage‐adjusted mortality ratesatrial fibrillationcardiomyopathyethnicitygeographic regionsracesex

Identifiers

PMID41085136
PMCPMC12671472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.