Evidence map›Paper›PMID 41085124›Full record

Observational studyAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Cross-country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia.

Liset de Boer, Lize C Jiskoot, Harro Seelaar, John C van Swieten, Agustin Ibanez, Marcelo Maito, Sol Fittipaldi, Julie F H De Houwer, Tine Swartenbroekx, Pam A Boesjes and 36 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Liset de BoerAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0009-0007-7161-3559
Lize C JiskootAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Harro SeelaarAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
John C van SwietenAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Agustin IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Peñalolén, Santiago de Chile, Chile.
Marcelo MaitoLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Peñalolén, Santiago de Chile, Chile.
Sol FittipaldiLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Peñalolén, Santiago de Chile, Chile.
Julie F H De HouwerAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Tine SwartenbroekxAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Pam A BoesjesAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Rhian S ConveryDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Eve Ferry-BolderDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Phoebe FosterDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Arabella BouziguesDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Lucy Chisman-RussellDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Esther van den BergAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Janne PapmaAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Sanne FranzenAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Renelle BourdageAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Barbara BorroniDepartment of Clinical and Experimental Sciences, University of Brescia, Viale Europa, Brescia, Italy.
Daniela GalimbertiFondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Pietro TiraboschiFondazione IRCCS Institute Neurologico Carlo Besta, Milan, Italy.
Mario MasellisSunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.
Elizabeth FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada.
Robert LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, and Faculté de Médecine, Université Laval, Rue Québec (Qc), QC, Canada.
Caroline GraffDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet, Solna, Sweden.
Alexander GerhardDivision of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Withington, Manchester, UK.
Raquel Sanchez-ValleAlzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain.
Alexandre MendonçaFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Fermin MorenoCognitive Disorders Unit, Department of Neurology, Donostia Universitary Hospital, Donostia, San Sebastian, Spain.
Matthis SynofzikDepartment of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Simon DucharmeDepartment of Psychiatry, Douglas Mental Health University Institute and Montreal Neurological Institute, McGill University, Montréal, Québec, Canada.
Isabelle Le BerSorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié, Paris, France.
Johannes LevinDepartment of Neurology, LMU University Hospital, LMU, Munich, Germany.
Thibaud LebouvierUniv. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, Inserm, Rue Michel Polonowski, Lille, France.
Benedetta NacmiasDepartment of Neurofarba, University of Florence, Firenze, Italy.
Markus OttoDepartment of Neurology, University of Ulm, Ulm, Germany.
Christopher R ButlerNuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.
Isabel SantanaUniversity Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Maxime BertouxUniv. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, Inserm, Rue Michel Polonowski, Lille, France.
M Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Jackie M PoosAlzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-8843-7247
GENFI Consortium

Funding

Alzheimer FoundationAlzheimer Nederland WE.08-2023-05Alzheimer's Research UK Clinical Research Training Fellowship ARUK-CRF2017B-2Association for Frontotemporal Dementias Research 2009Bluefield ProjectBrain FoundationCambridge University Centre for Frontotemporal DementiaCanadian Institute of Health Research operating grant 327387Carlos III Health Institute PI19/01637Dementia FoundationDeutsche Forschungsgemeinschaft German Research Foundation under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems NeurologyMunich Cluster for Systems Neurology 390857198EU-Horizon project PREDICTFTD 102256175EU Joint Programme-Neurodegenerative Disease ResearchEU Joint Programme-Neurodegenerative Disease Research GENFI-PROX grant 2019-02248EU Joint Programme-Neurodegenerative Disease Research-Prefrontals Vetenskapsrådet Dnr 2015-02926EU Joint Programme-Neurodegenerative Disease Research-Prefrontals Vetenskapsrådet Dnr 2018-0275EU Joint Programme-Neurodegenerative Disease Research-Prefrontals Vetenskapsrådet Dnr 2019-0224EU Joint Programme-Neurodegenerative Disease Research-Prefrontals Vetenskapsrådet Dnr 529-2014-7504European Reference Network for Rare Neurological Diseases (ERN-RND) 739510Fundació Marató de TV3 20143810Germany's Federal Ministry of Education and Research (BMBF)Gieskes-Strijbis fondsItalian Ministry of Health (PreFrontALS) grant 733051042Mady Browaeys Fund for Research into Frontotemporal DementiaMedical Research Council MC_UU_00030/14Medical Research Council MR/T033371/1Miriam Marks Brain Research UK Senior FellowshipMRC Clinician Scientist Fellowship MR/M008525/1National Institute for Health and Care Research University College London Hospitals Biomedical Research CentreNational Institute for Health Research Cambridge Biomedical Research Centre NIHR203312Netherlands Organization for Scientific Research HCMI 056-13-018Region Stockholm ALF-projectStichting Dioraphte 09-02-03-00Swedish FTD Inititative-Schörling FoundationTau ConsortiumWellcome Trust 103838Wellcome Trust 220258ZonMw Memorabel 733 051 042ZonMw Onderzoeksprogramma Dementie (YOD-INCLUDED) 10510032120002
6 · The paper itself

Abstract

introductionWe investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries.

methodsAn FER test was administered to 159 individuals with behavioral variant FTD, 521 presymptomatic pathogenic variant carriers, and 583 controls from 16 countries of residence. Linear mixed models assessed age, sex, education, and country effects on FER. Voxel-based morphometry examined neural correlates across countries. REULTS: Country accounted for 18%-18.3% of FER variance in presymptomatic carriers and controls and 9.9% in individuals with behavioral variant of FTD (bvFTD). Cross-country differences interacted with the effects of sex, age, and education. Neural correlates involving the frontal lobe and basal ganglia were identified in individuals with bvFTD, but no cross-country differences were found. DISCUSSION: These results underscore the need for culturally sensitive FER tools in research and clinical practice, especially as global multinational clinical trials emerge. HIGHLIGHTS: Performance on a test for facial emotion recognition (FER) varies between countries. The percentage of variance is lower in the behavioral variant of frontotemporal dementia (bvFTD) compared to presymptomatic pathogenic variant carriers and healthy controls. Cross-country differences interacted with the effects of sex, age, and education. There were no differences in brain correlates of FER across countries.

Indexed as

Cross-Cultural ComparisonFacial RecognitionFrontotemporal DementiaAdultAgedCanadaCase-Control StudiesEmotionsEuropeFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Testscultural diversityfacial emotion recognitionfrontotemporal dementiapresymptomaticsocial cognition

Identifiers

PMID41085124
PMCPMC12519523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.