ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2025
VERMONT: Vessel Fractional Flow Reserve (vFFR) Assessment of Stenosis Severity: A Prospective Study.
Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- VERMONT μQFR: Diagnostic Accuracy of Murray Law-Based 2D-μQFR Compared to 3D-μQFR and vFFR.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- VERMONT non-optimised: Feasibility of angiography-derived vFFR using baseline diagnostic catheter images.International journal of cardiology. Heart & vasculature · 2026Article
- VERMONT: Vessel Fractional Flow Reserve (vFFR) Assessment of Stenosis Severity: A Prospective Study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundVessel fractional flow reserve (vFFR) is an angiogram-based technique validated in early studies; however, data on its real-time diagnostic performance and integration into routine workflow remain limited.
aimsThe VERMONT study evaluated the diagnostic accuracy and time efficiency of real-time vFFR versus conventional wire-based FFR in detecting functionally significant coronary lesions.
methodsWe conducted a prospective, single-center, blinded study in which vFFR was measured during coronary angiography and compared with simultaneous wire-based FFR. A wire-based FFR of ≤ 0.80 defined a physiologically significant lesion.
resultsIn 209 patients with 225 intermediate lesions, only 20 (8.9%) of lesions were excluded from vFFR analysis. vFFR demonstrated an AUC of 0.92 (95% CI, 0.89-0.96) for detecting lesions with FFR ≤ 0.80, achieving 90% sensitivity, 79% specificity, a negative predictive value of 93%, and a positive predictive value of 74%. Interobserver agreement was excellent (r = 0.97, p < 0.001). Real-time vFFR computation was on average 13.9 min faster than wire-based FFR (p < 0.001).
conclusionReal-time vFFR demonstrated excellent diagnostic performance with high sensitivity and NPV for identifying functionally significant intermediate lesions, supporting its use as a reliable screening tool. Importantly, this was achieved with a low exclusion rate, rapid computation time, and minimal interobserver variability, underscoring its practicality in routine clinical practice.
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