ArticleJournal of the American Chemical Society2025
Double Disguise: Camouflaging Photocages for Bioorthogonally Controlled Conditional Activation.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A focus on caging radicals: a catch-and-release mechanism for BODIPY photocages.Chemical science · 2026Article
- Subcellular photochemistry for precision spatial protein targeting.Nature reviews. Chemistry · 2026Review
- Optimized Xanthenium Photocages with Fused Ring Systems for Photoactivated Chemotherapy and G Protein-Coupled Receptor Photopharmacology.Journal of the American Chemical Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photocages provide excellent spatiotemporal control over biological processes; however, strategies to restrict their activation to specific conditions remain limited. In this work, we demonstrate that our recently introduced photocages based on the aminofluorone (rhodol) choromophore can be rendered completely inactive through a single substitution on the oxygen auxochrome. These 'camouflaged' photocages are entirely colorless, preventing photouncaging in their disabled state. Bioorthogonal removal of the camouflaging group restores the photoactivity of the cages, introducing an additional layer of control for photoassisted delivery systems. We further demonstrate this concept of substitution-dependent, bioorthogonally regulated photoactivation in a cellular context, where both a bioorthogonal reagent and light were required to release a potent topoisomerase inhibitor, SN38.
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Registered trials
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