SynthesisOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025
Characterizing Differences in Polysomnography Data for Children With Robin Sequence Undergoing Conservative and Surgical Management.
Synthesis in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectiveTo perform a meta-analysis of polysomnography (PSG) findings in infants with Robin sequence (RS). DATA SOURCES: CINAHL, Cochrane Library, PubMed, and Scopus. REVIEW
methodsStudies describing PSG results in infants with RS before and/or after intervention were included. Meta-analysis of mean difference (Δ), proportions (%), and continuous measures with 95% confidence interval (CI) were calculated using random and fixed effects models.
resultsIn total, 45 studies including 1881 infants were analyzed. The mean age at PSG was 24.89 (range 0-267) days, and 27.92% (CI 21.7-34.7) had an associated syndrome, with Stickler syndrome being most common (11.08%, CI 9.3-13.1). At baseline, 79.88% (CI 59.1-94.5) were diagnosed with severe obstructive sleep apnea. Most patients underwent a mandibular distraction osteogenesis (MDO, 66%), followed by conservative management (14%) or tongue-lip adhesion (TLA, 11%). Baseline apnea-hypopnea index (AHI) was highest in the TLA group (39.05/h, CI 8.4-69.7), compared to the MDO (31.48/h, CI 27.5-35.5) and conservative treatment groups (19.92/h, CI 15.6-24.2). There was an improvement in AHI following surgery by 24.52/h (CI 21.4-27.7) (P < .001) after MDO and by 25.38/h (CI 1.4-49.3) (P = .04) following TLA. Additionally, SpO
conclusionInfants with RS with an AHI approaching 30 tended to undergo surgical intervention. PSG findings improved significantly following MDO and TLA, with few requiring further surgeries including tracheostomy. Future research should explore integrating PSG results with clinical data to inform an algorithm for management.
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