Evidence map›Paper›PMID 41085055›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Spatially Programmable Electroadhesive Enables In Situ Site-Selective Functional Coupling.

Yuting Guo, Zhuoming Liang, Guoshi Xu, Zhen Gu, Yuheng Xu, Michael Raphael Panganiban, Xue Cai, Jet Yong Kiat Lim, Jiguang Zhang, Jingxiu Huang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuting GuoDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.ORCID 0009-0009-8671-2984
Zhuoming LiangDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Guoshi XuHuman Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, 100101, China.
Zhen GuSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Yuheng XuDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Michael Raphael PanganibanDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Xue CaiDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Jet Yong Kiat LimDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Jiguang ZhangDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
Jingxiu HuangDepartment of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Tingting FanHuman Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, 100101, China.
Qi GuHuman Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, 100101, China.
Yuxin LiuDepartment of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.ORCID 0000-0002-6425-6510

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise intraoperative integration of bioelectronic devices with wet tissue surfaces remains a challenge due to the limited spatial control of adhesion sites. Here, an in situ spatially programmable electrical bioadhesive (termed "STICH") is reported that enables site-selective adhesion and functional coupling via light-activated bonding with wet biological tissue. Upon irradiation with patterned green light, Rose Bengal in a chitosan/silver nanowire hydrogel matrix generates singlet oxygen, which oxidizes amino acid residues into carbonyl groups on the tissue surface. The covalent bonding is then formed between the newly formed reactive carbonyl group and amine groups on chitosan. The spatially programmable adhesive allows robust tissue bonding with a lap-shear strength of 160 kPa and precise adhesion regions at ≈2 µm resolution. The light-patternable adhesive enables spatially resolved mechanical coupling for directional electromechanical sensing on ex vivo cardiac tissue. The low impedance adhesive interface also provides spatially programmed electrical coupling for in vivo neuromuscular stimulation on intraoperatively selected muscle groups. This platform advances microscale device-tissue integration and paves the way for reconfigurable bioelectronic therapies.

Indexed as

Implants, ExperimentalAnimalsChitosanHydrogelsLightNanowiresRose BengalSilverSinglet OxygenChitosanHydrogelsRose BengalSilverSinglet Oxygenbioadhesive interfacesmechanical and electrical couplingspatially programmable

Identifiers

PMID41085055
PMCPMC12710562

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.