ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Synergistic Anti-Cancer Therapy Through Ultrasound-Induced Piezocatalytic Therapy and Tumor Treatment Fields.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Next-generation dynamic and combinatorial nanotherapies for liver cancer: mechanisms, current advances and future perspectives.Journal of nanobiotechnology · 2026Review
- Synergistic Anti-Cancer Therapy Through Ultrasound-Induced Piezocatalytic Therapy and Tumor Treatment Fields.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual-modal Fe-MOF-derived piezoelectric nanofibers enable combinatorial tumor suppression via tumor treating fields and magnetic hyperthermia.Science and technology of advanced materials · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The integration of therapeutic modalities to enhance cancer treatment efficacy and improve patient outcomes offers remarkable benefits over monotherapies and has attracted considerable attention. Herein, a synergistic anti-cancer therapy leveraging the benefits of physical tumor treating fields (TTFs) and dynamic piezocatalytic therapy (PCT) is presented, aiming to offer an optimized scheme while minimizing systemic side effects. First, a wearable ultrasound-induced wireless energy harvester based on biocompatible lead-free potassium sodium niobate-based piezocomposites is developed to enable efficient acoustic-to-electric conversion. The flexible printed circuit board architecture with two pairs of half-ring electrodes not only generates wide-anging alternating electric fields but also facilitates easy fixation and wearability. Second, biocompatible piezoelectric nanoparticles (NPs) serve as the piezocatalysts to promote the generation of reactive oxygen species (ROS) and to directly interfere with biological processes. Finally, in vivo evaluations using mouse models demonstrate that the combination of ultrasound-activated PCT and TTFs significantly inhibits tumor growth and modulates the tumor immune microenvironment. Notably, prominent synergistic antitumor effects are also observed in patient-derived xenograft (PDX) models of head and neck squamous cell carcinoma (HNSCC), highlighting a versatile approach to advance cancer treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.