ArticleFuture microbiology2025
Chlorpromazine, impregnated in foley catheter fragments, as an antibiofilm agent to control urinary tract infections.
Article in Future microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
backgroundThe study proposes to evaluate the impregnation of Foley catheters, in different concentrations of CPZ, to control the formation of biofilms in vitro by the uropathogens most commonly associated with indwelling catheters. MATERIALS &
methodsMinimum inhibitory concentrations (MICs) for CPZ and the effect of CPZ (at different concentrations) on biofilm formation were evaluated. Biofilm formation and the effect of CIP and MER on mature biofilms in CPZ-impregnated catheters were evaluated.
resultsThe CPZ MIC was 312.5-625 µg/ml. CPZ significantly (p < 0.05) disrupted biofilm formation at all tested concentrations. In addition, the tested CPZ potentiated the action of CIP.
conclusionsOur results suggest the use of CPZ by impregnation of catheters can prevent the formation of bacterial biofilms, preventing urinary infections through this route.
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