Evidence map›Paper›PMID 41084803›Full record

ArticleCirculation. Arrhythmia and electrophysiology2025

Lysosomal Ca

An Xie, Gyeoung-Jin Kang, Hong Liu, Eun Ji Kim, Feng Feng, Dobromir Dobrev, Samuel C Dudley

Abstract read
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In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

An Xie *Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (A.X., G.-J.K., H.L., E.J.K., F.F., S.C.D.).ORCID 0009-0003-5580-8023
Gyeoung-Jin Kang *Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (A.X., G.-J.K., H.L., E.J.K., F.F., S.C.D.).ORCID 0000-0003-0646-9187
Hong LiuDepartment of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (A.X., G.-J.K., H.L., E.J.K., F.F., S.C.D.).ORCID 0000-0002-4079-6985
Eun Ji KimDepartment of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (A.X., G.-J.K., H.L., E.J.K., F.F., S.C.D.).ORCID 0000-0002-3271-1419
Feng FengDepartment of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (A.X., G.-J.K., H.L., E.J.K., F.F., S.C.D.).ORCID 0000-0001-9912-4318
Dobromir DobrevFaculty of Medicine, Institute of Pharmacology, University Duisburg-Essen, Germany (D.D.).ORCID 0000-0002-4612-117X
Samuel C DudleyDepartment of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (A.X., G.-J.K., H.L., E.J.K., F.F., S.C.D.).ORCID 0000-0001-5843-5961

Funding

Resolution of inflammation and atrial fibrillationR01HL165704 · NHLBI · UNIVERSITY OF MINNESOTA · PI SAMUEL C DUDLEY · 2023 to 2026
$2.9M
Training Program in Cardiac InnovationT32HL144472 · NHLBI · UNIVERSITY OF MINNESOTA · PI Peter A Crawford, SAMUEL C DUDLEY · 2019 to 2026
$2.6M
Lysosomes and arrhythmiaR01HL177974 · NHLBI · UNIVERSITY OF MINNESOTA · PI SAMUEL C DUDLEY · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL165704NHLBI NIH HHS R01 HL177974NHLBI NIH HHS T32 HL144472
6 · The paper itself

Abstract

backgroundIn nonischemic cardiomyopathy, mitochondrial Ca

methodsIschemic cardiomyopathy was induced in wild-type C57BL/6J and TRPML1 heterozygous knockdown (TRPML1±) mice by ligating the left anterior descending coronary artery. Mice were studied at 3 weeks after myocardial infarction (MI).

resultsAfter MI, the lysosomal-restricted TRPML1 Ca

conclusionsLysosomes contribute to arrhythmic risk after MI because of increased number, proximity to the SR, and induction of diastolic SR Ca

Indexed as

Arrhythmias, CardiacCalciumCalcium SignalingLysosomesMyocardial InfarctionMyocytes, CardiacTransient Receptor Potential ChannelsAction PotentialsAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLSarcoplasmic ReticulumCalciumMCOLN1 protein, humanMcoln1 protein, mouseTransient Receptor Potential Channelsarrhythmias, cardiaccalciumlysosomesmyocardial infarctionmyocytes, cardiac

Identifiers

PMID41084803
PMCPMC12629118

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.