ArticleCureus2025
Radiopathologic Characteristics of Invasive Mammary Carcinoma With Medullary Features: A Correlative Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Invasive mammary carcinoma with medullary features represents an uncommon subtype of breast cancer. Despite their high-grade histological appearances, they have a favourable prognosis. This study aims to correlate its radiologic and histopathologic characteristics. A comprehensive understanding of the radiopathologic profile is essential for enhancing the diagnosis precision and guiding patient treatment, particularly because of its typically benign imaging findings, which may result in misinterpretation and underdiagnosis. Materials and methods A retrospective observational study was conducted by reviewing cases of histologically confirmed invasive mammary carcinoma with medullary features and triple-negative basal-like carcinoma that met the WHO criteria over five years (2020-2025) at the Sri Ramachandra Institute of Higher Education and Research, Chennai, India. We reviewed preoperative mammographic and ultrasound features and compared them with histopathological findings. Descriptive statistics summarise the prevalence of each feature. Results We included a total of 45 patients (age range: 25-76 years) with a confirmed diagnosis of medullary carcinoma. On mammograms, 30 (90.9%) had a detectable mass, of which 16 (53.3%) presented as an irregular shape with circumscribed margins and equal density. Rarely were calcifications identified, and they were present only in three (10%) cases. Sonographic examination revealed 29 (83%) cases as hypoechoic; 26 (74%) irregular masses, with microlobulated margins in 18 (51.4%) cases; and posterior acoustic enhancement in 32 (91%) cases. Eighteen (51%) of the masses showed minimal internal vascularity. Histopathology confirmed that 42 (93%) of the cases showed a syncytial growth pattern, with 39 (86%) having a high nuclear grade and 44 (97.8%) showing no glandular or tubular elements. There were prominent lymphoplasmacytic infiltrates in 100% of cases, and they were all triple-negative immunophenotypes. Conclusion Medullary carcinoma can present similarly to benign lesions in imaging studies, exhibiting characteristics like circumscribed morphology and posterior acoustic enhancement. Despite these similarities, imaging techniques cannot definitively differentiate medullary carcinoma from other types of breast lesions, making it essential to conduct a biopsy and obtain histopathological confirmation for a conclusive, timely, and accurate diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.