ArticleCureus2025
Sun-Induced Severe Symptomatic Hypercalcemia in a Patient With Sarcoidosis: A Case Report Highlighting the Importance of Patient Education and Early Recognition.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Sarcoidosis is a multisystem inflammatory disorder characterized by non-caseating granulomas that can disrupt calcium metabolism through extrarenal production of calcitriol. In affected individuals, sun exposure may precipitate severe symptomatic hypercalcemia. We present the case of a 46-year-old male patient who initially presented with acute foot pain and was incidentally found to have extensive lymphadenopathy. Biopsy confirmed sarcoidosis, but the patient was lost to follow-up. One year later, after a two-week sun holiday, he developed severe hypercalcemia and acute kidney injury, presenting with fatigue, hypersomnia, and gastrointestinal symptoms. Standard treatments for hypercalcemia were ineffective, but rapid clinical improvement occurred with the initiation of corticosteroid therapy. This case highlights the importance of educating patients with sarcoidosis about the risks of sun exposure and underscores the necessity of disease-specific treatment, as corticosteroids are crucial for managing sarcoidosis-induced hypercalcemia.
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