ArticleCureus2025
Diffusion-Weighted Magnetic Resonance Imaging in Suspicious Breast Lesions Detected on Ultrasonography and Mammography With Pathological Correlation.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Introduction Diffusion-weighted magnetic resonance imaging (DW-MRI), an advanced functional imaging method, offers a notable advantage over traditional dynamic contrast-enhanced MRI (DCE-MRI) by generating tissue contrast without requiring the injection of intravenous contrast agents. The aim of the study is to evaluate the role of DW-MRI in suspicious breast lesions encountered primarily on ultrasonographic and mammographic evaluation. Methods A hospital-based cross-sectional study was performed between July 2023 and December 2023, including 34 suspicious breast lesions in 32 females detected on ultrasonography and mammography. Cases underwent MRI on a 1.5 Tesla scanner using a dedicated breast coil. DW MRI was done with b-values of 500, 800, and 1000 s/mm². Lesions were characterized by ultrasonography and mammography as per the ACR BI-RADS lexicon. Histopathological diagnosis was considered the gold standard of reference. Results Of 34 breast lesions, 16 (47.1%) were benign and 18 (52.9%) were malignant. The cut-off ADC value derived by the receiver operating characteristic (ROC) curve was 1.12 x10-3 mm²/s using different b values of 500, 800, and 1000 s/mm², which yielded optimal sensitivity (88.6%) and specificity (78.6%). The mean apparent diffusion coefficient (ADC) values of benign and malignant lesions were 1.51±0.22 x10-3 mm²/s and 1.0±0.09x10-3 mm²/s, respectively (p<0.0001). The mean ADC value of normal breast parenchyma was 1.68 ± 0.02 x 10-3 mm²/s (p<0.0001). DW‑MRI achieved a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of DW-MRI by using ADC mapping that were found to be 88.6%, 78.6%, 83.8%, 84.6%, and 84.1%, respectively, in this study. Conclusion DW-MRI can be a potential adjunct to routine screening and diagnostic modalities and can be used as a problem-solving tool in suspicious breast lesions encountered on conventional imaging.
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