ReviewSage open pediatrics
Epigenetics and Environmental Exposures in Early Neurodevelopment: Implications for Pediatric Neurological Disorders.
Review in Sage open pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A Clinical Practice Example of Smith-Magenis Syndrome in the Neuropediatric Clinic: Etiology, Clinical Presentation, Diagnostics and Therapeutic Approaches-A Case Report.Children (Basel, Switzerland) · 2026Article
- The Evolving ADHD Phenotype in the Externalizing Context.The American journal of psychiatry · 2026Review
- Hierarchical-Circular Model of Biological Memory: an integrative framework for pathogenesis and allostasis in neurodevelopmental disorders.Frontiers in behavioral neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric neurological disorders such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are increasingly understood to arise from complex interactions between genetics and environmental factors. Emerging evidence highlights the role of epigenetic mechanisms, particularly DNA methylation, histone modification, and non-coding RNAs, in mediating how early-life exposures shape brain development. This review synthesizes findings from 48 recent studies, including human cohorts and animal models, linking prenatal stress, maternal nutrition, endocrine disruptors, and air pollution to epigenetic alterations that disrupt neurogenesis, synaptic plasticity, and neural differentiation. These mechanisms offer insight into clinical phenomena and open potential for early screening and epigenetic interventions in pediatric neurology. The main finding reveals that early environmental exposures can leave lasting epigenetic marks that significantly influence neurodevelopment and contribute to pediatric neurological disorders.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.