ArticleClinical, cosmetic and investigational dermatology2025
DNA Methylation at cg18095732 Modulates ZDHHC20 Expression and Decreases Acne Vulgaris Risk.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exposome involvement in the development of acne vulgaris.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acne vulgaris is a common chronic inflammatory skin disorder involving lipid metabolism and immune dysregulation. Protein S-palmitoylation regulates lipid homeostasis, while DNA methylation has emerged as a potential contributor to acne pathogenesis. Yet, how DNA methylation and palmitoylation intersect in acne remains unclear. Methods: The objective of this study was to investigate whether palmitoylation-related genes are causally linked to acne by integrating large-scale genetic and epigenetic datasets through Mendelian randomization and complementary analyses. Results: Our MR and SMR analyses identified ZDHHC20, a gene encoding a palmitoyltransferase, as significantly and negatively associated with acne risk. Further mediation analysis revealed that hypermethylation at the CpG site cg18095732 was positively associated with ZDHHC20 expression and indirectly contributed to a reduced risk of acne. This methylation site accounted for 61.90% of the total effect via mediation. Robustness of the findings was confirmed through sensitivity analyses, which indicated no evidence of horizontal pleiotropy or heterogeneity. Conclusion: This study provides supportive evidence for a regulatory pathway in which DNA methylation at cg18095732 up-regulates ZDHHC20 and is associated with lower acne susceptibility. Our findings highlight epigenetic regulation as a potential biomarker or intervention point for inflammatory skin disorders.
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Registered trials
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