ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2025
The Association Study of Targeted DNA Methylation and Thrombophilia.
Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The aim of this study is to investigate the relationship of leukocytes DNA methylation in targeted sites and thrombophilia. Methods: Eight thrombophilia patients and their kin-related individuals as the healthy control. Targeted DNA methylation from peripheral leukocytes were examined with MassArray. Multivariate correlation analysis was used to estimate targeted gene methylation as an independent risk factor of thrombophilia. Receiver operating characteristic curve analysis was used to calculate the accuracy of biomarkers in the prediction of thrombophilia. Results: The age of thrombophilia group was higher than control group ( Conclusion: Target DNA methylation in Protein S.44.CpG.29-33 island is associated with an elevated risk of thrombophilia.
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