ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2025
Impact of Dasatinib on Female Reproductive Health in Philadelphia-Positive Leukemia Patients.
Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML), with patients now achieving life expectancy comparable to the general population. Despite the contraindication of TKIs during the first trimester of pregnancy, their effects on female reproductive health remain underexplored. This pilot case-control study evaluated the impact of Dasatinib on the female reproductive system in 25 women with CML or Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL), compared to 25 age-matched controls. Clinical histories, gynecological examinations, transvaginal ultrasonography, and serum Anti-Müllerian hormone (AMH) assessments were performed. There was no significant differences in menstrual cycle characteristics between patients and controls, although 12% of patients experienced shorter cycles and 8% reported heavier menstrual flow after initiating Dasatinib. Notably, patients on Dasatinib had significantly lower serum AMH levels (
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