ArticleTransfusion2026
Diagnosis and management of post-transfusion purpura in the acute trauma setting: A case report.
Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
backgroundPost-transfusion purpura (PTP) is a rare and severe transfusion reaction characterized by rapid-onset thrombocytopenia, typically occurring 1-2 weeks after platelet or RBC transfusion. While PTP is commonly seen in patients with prior pregnancies or transfusions, its occurrence in trauma patients has rarely been reported. We present a case highlighting the challenges of PTP diagnosis and management in the post-trauma setting. CASE REPORT: A 38-year-old female was airlifted to Harborview Medical Center, Seattle, WA, USA, following a motor vehicle accident, requiring administration of blood products via massive transfusion protocol. On hospital Day 8, she developed abrupt and significant thrombocytopenia, with a drop in platelets from 157 × 10 DISCUSSION: This case emphasizes the complexity of diagnosing PTP in the acute trauma setting following massive transfusion protocol. Effective communication between the transfusion medicine, hematology/oncology, and trauma surgery teams was crucial to successfully manage this patient, highlighting the importance of a supportive multidisciplinary approach in these complex clinical scenarios.
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