SynthesisEndocrinology, diabetes & metabolism2025
Are Bifidobacterium Species Key Players in the Progression of Type 1 Diabetes? A Systematic Review.
Synthesis in Endocrinology, diabetes & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Are Bifidobacterium Species Key Players in the Progression of Type 1 Diabetes? A Systematic Review.Endocrinology, diabetes & metabolism · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundType 1 diabetes (T1D) frequently develops in childhood and is preceded by a non-symptomatic period of autoimmunity. Alterations in the gut microbiome are implicated in T1D pathogenesis. Bifidobacterium is a significant focus due to its positive health impacts, association with breastfeeding and presence in probiotics and infant milk-formulas. This systematic review aims to investigate Bifidobacterium's association with T1D across disease stages.
methodsA comprehensive electronic search was conducted in MEDLINE, EMBASE and Web of Science, from 2011 to 2024. The search used a combination of medical subject headings and keywords related to Bifidobacterium. Studies included individuals at risk of T1D (pre-stage, stage 1 or 2 asymptomatic T1D) and with stage 3 symptomatic T1D while excluding T2D, clinical trials and animal studies.
resultsThe search initially retrieved 1120 articles. Of these, 25 papers met the inclusion criteria, covering 4533 individuals (842 cases with or at-risk of T1D and 3691 healthy controls). The studies highlighted variability in Bifidobacterium abundance in T1D, with higher abundance found more often in at-risk asymptomatic individuals and lower abundance frequently found in those with established T1D.
conclusionThese findings do not support loss of Bifidobacterium as a key factor in the early development of T1D. Further studies are needed to explore Bifidobacterium's role in T1D progression and management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.